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Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via nuclear factor-kappa B activation

Shengjie Cui Yan Liu Xuedong Wang Yanning Guo Yu Fu Ting Zhang Jieni Zhang Yehua Gan Yanheng Zhou Yan Gu Eileen Gentleman

国际口腔科学杂志（英文版）2025，Vol.17Issue(2)：221-232,12.

国际口腔科学杂志（英文版）2025，Vol.17Issue(2)：221-232,12.DOI:10.1038/s41368-025-00352-0

Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via nuclear factor-kappa B activation

Shengjie Cui ¹Yan Liu ²Xuedong Wang ³Yanning Guo ³Yu Fu ⁴Ting Zhang ³Jieni Zhang ³Yehua Gan ⁵Yanheng Zhou ³Yan Gu ³Eileen Gentleman⁶

作者信息

1. Department of Orthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China||Department of General Dentistry,Peking University School and Hospital of Stomatology,Beijing,China
2. Department of Orthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China||Central Laboratory,Peking University School and Hospital of Stomatology,Beijing,China
3. Department of Orthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China
4. Fourth Clinical Division,Peking University School and Hospital of Stomatology,Beijing,China
5. Center for Temporomandibular Disorders and Orofacial Pain,Peking University School and Hospital of Stomatology,Beijing,China
6. Centre for Craniofacial and Regenerative Biology,King's College London,London,UK
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摘要

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Shengjie Cui,Yan Liu,Xuedong Wang,Yanning Guo,Yu Fu,Ting Zhang,Jieni Zhang,Yehua Gan,Yanheng Zhou,Yan Gu,Eileen Gentleman..Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via nuclear factor-kappa B activation[J].国际口腔科学杂志（英文版）,2025,17(2):221-232,12.

基金项目

This project is supported by the National Natural Science Foundation of China Nos.82370983,81671015(X.W.),82230030(Y.L.),82101043(S.C.)and 82370922(Y.F.),Beijing International Science and Technology Cooperation Project No.Z221100002722003(Y.L.),Beijing Natural Science Foundation Nos.L234017,JL23002(Y.L.),No.7242282(S.C.)and 7232217(Y.G.),Clinical Medicine Plus X-Young Scholars Project of Peking University No.PKU2024LCXQ039(Y.L.),National Program for Multidisciplinary Cooperative Treatment on Major Diseases No.PKUSSNMP-202013(X.W.),Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing No.HP2023-12-509001(J.Z.),and Young Clinical Research Fund of the Chinese Stomatological Association No.CSA-02022-03(J.Z.).We thank the Center for Biological Imaging,Institute of Biophysics of the Chinese Academy of Sciences,for our TEM work and we be grateful to Dr.Lei Sun and Can Peng for making TEM sample and taking TEM images. （X.W.）

国际口腔科学杂志（英文版）

ISSN：1674-2818

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