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Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

Feilong Ren Shize Zheng Huanyu Luo Xiaoyi Yu Xianjing Li Shaoyi Song Wenhuan Bu Hongchen Sun

国际口腔科学杂志（英文版）2025，Vol.17Issue(2)：255-267,13.

国际口腔科学杂志（英文版）2025，Vol.17Issue(2)：255-267,13.DOI:10.1038/s41368-025-00361-z

Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation

Feilong Ren ¹Shize Zheng ¹Huanyu Luo ¹Xiaoyi Yu ²Xianjing Li ³Shaoyi Song ¹Wenhuan Bu ²Hongchen Sun¹

作者信息

1. Hospital of Stomatology,Jilin University,Changchun,China||Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,School and Hospital of Stomatology,Jilin University,Changchun,China
2. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,School and Hospital of Stomatology,Jilin University,Changchun,China||Jilin Provincial Key Laboratory Oral Biomedical Engineering,Jilin University,Changchun,China
3. Hospital of Stomatology,Jilin University,Changchun,China
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摘要

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Feilong Ren,Shize Zheng,Huanyu Luo,Xiaoyi Yu,Xianjing Li,Shaoyi Song,Wenhuan Bu,Hongchen Sun..Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation[J].国际口腔科学杂志（英文版）,2025,17(2):255-267,13.

基金项目

This study was supported by the National Key R&D Program of China(No.2022YFC2504200)and the National Natural Science Foundation of China(Nos.82370936,81920108012,82471032).Authors also wish to thank Ichiro Nishimura and Niki Maria Moutsopoulos for their support with the single-cell sequencing data of gingival tissues. （No.2022YFC2504200）

国际口腔科学杂志（英文版）

ISSN：1674-2818

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