国际医药卫生导报2025，Vol.31Issue(9)：1440-1444,5.DOI:10.3760/cma.j.cn441417-20240703-09007
脊柱结核患者血清S100A12、外周血RDW、Mono％水平及临床意义
Levels of serum S100A12 and peripheral blood RDW and Mono％and their clinical significance in patients with spinal tuberculosis and their clinical significance
摘要
Abstract
Objective To investigate the levels of serum S100 calcium-binding protein A12(S100A12)and peripheral blood red cell distribution width(RDW)and monocyte percentage(Mono％)in patients with spinal tuberculosis and their clinical significance.Methods A total of 80 patients with spinal tuberculosis admitted to Xianyang Central Hospital from February 2021 to May 2023 were selected as an observation group,including 44 males and 36 females,aged(41.78±8.58)years,and 60 healthy individuals who underwent physical examination during the same period were selected as a control group,including 33 males and 27 females,aged(39.49±9.90)years.The levels of serum S100A12 and peripheral blood RDW and Mono％of the two groups were detected,and the diagnostic efficacies of the three indexes for spinal tuberculosis were analyzed by the receiver operating characteristic curve(ROC).The observation group of 80 patients with spinal tuberculosis were followed up for 1 year,and were divided into a recurrence group(23 cases)and a non-recurrence group(57 cases)based on recurrence.The predictive efficacies of serum S100A12 and peripheral blood RDW and Mono％for spinal tuberculosis recurrence were analyzed.Independent sample t test was used for statistical analysis.Results The levels of serum S100A12 and peripheral blood RDW and Mono％in the observation group were higher than those in control group[(149.08±43.76)ng/L vs.(88.36±20.26)ng/L,(14.44±1.55)％vs.(12.97±1.31)％,(9.27±1.62)％vs.(8.03±1.38)％],with statistically significant differences(all P＜0.05).ROC analysis showed that the sensitivity of S100A12 was 73.8％,the specificity was 98.3％,and the area under the curve(AUC)was 0.894 in the diagnosis of spinal tuberculosis;the sensitivity of RDW was 68.8％,the specificity was 78.3％,and the AUC was 0.767;the sensitivity of Mono％was 68.8％,the specificity was 68.3％,and the AUC was 0.726.However,when S100A12,RDW,and Mono％were combined for diagnosis,the sensitivity and specificity were 87.5％and 95.0％,respectively,with an AUC of 0.948,indicating high diagnostic efficacy with combined testing.The levels of serum S100A12 and peripheral blood RDW and Mono％in the recurrence group were higher than those in the non-recurrence group[(177.36±47.59)ng/L vs.(137.67±36.76)ng/L,(15.40±1.55)％vs.(14.05±1.39)％,(9.91±1.68)％vs.(9.01±1.53)％],with statistically significant differences(all P＜0.05).ROC analysis showed that the sensitivity of S100A12 was 56.5％,the specificity was 89.5％,and the AUC was 0.757 in predicting the recurrence of spinal tuberculosis;the sensitivity of RDW was 78.3％,the specificity was 68.4％,and the AUC was 0.755;the sensitivity of Mono％was 82.6％,the specificity was 56.1％,and the AUC was 0.698.However,when S100A12,RDW,and Mono％were combined for prediction,the sensitivity and specificity increased to 82.6％and 84.2％,respectively,with an AUC of 0.863,indicating high predictive efficacy with combined testing.Conclusion Serum S100A12 and peripheral blood RDW and Mono％can be used to diagnose spinal tuberculosis and have certain value in predicting recurrence.关键词
脊柱结核/钙结合蛋白A12/红细胞分布宽度/单核细胞百分比Key words
Spinal tuberculosis/S100 calcium-binding protein A12/Red cell distribution width/Monocyte percentage引用本文复制引用
马航,张冰..脊柱结核患者血清S100A12、外周血RDW、Mono％水平及临床意义[J].国际医药卫生导报,2025,31(9):1440-1444,5.基金项目
陕西省重点研发计划(2022SF—413) Shaanxi Province Key Research and Development Plan(2022SF-413) （2022SF—413）
