国际医药卫生导报2025，Vol.31Issue(10)：1586-1591,6.DOI:10.3760/cma.j.cn441417-20250306-10001
2型糖尿病通过影响肠道菌群增加子痫前期的风险
Type 2 diabetes increases the risk of preeclampsia through alterations in gut microbiota
摘要
Abstract
Objective To analyze the potential role of gut microbiota in elevating the risk of preeclampsia in individuals with diabetes by Mendelian randomization(MR).Methods The study was carried out at Yantaishan Hospital from September to November 2024.The data of Genome-Wide Association Studies(GWAS)extracted from the IEU OpenGWAS public database.This study analyzed three large diabetic cohorts(n=461 578,520 580,and 659 316),along with preeclampsia(n=118 291)and eclampsia(n=11 729)cohorts.The two-step MR method was employed to evaluate the mediating effect of gut microbiota on the relationship between diabetes and preeclampsia.Additionally,the GWAS data for gut microbiota included 211 taxa derived from 14 306 European participants.The MR-Egger regression intercept and Cochran's Q were used to evaluate the pleiotropy and heterogeneity.The sensitivity was analyzed by the leave-one-out method.Results Types 1 and 2 diabetes were both associated with increased risk of preeclampsia(OR=1.05 and 1.15).Among the 211 gut microbiota taxa analyzed,the effect values of Olsenella for preeclampsia was 0.12(P=0.003);the effect value of type 2 diabetes for preeclampsia was 0.14(P=8.23E-05).Olsenella was related to type 2 diabetes and preeclampsia.The MR indicated that Olsenella partially mediated the effect of type 2 diabetes on preeclampsia,accounting for 6％of the total effect.Conclusion Type 2 diabetes may increase the risk of preeclampsia via gut microbiota.关键词
2型糖尿病/子痫前期/肠道菌群/孟德尔随机化Key words
Type 2 diabetes/Preeclampsia/Gut microbiota/Mendelian randomization引用本文复制引用
杨海燕,宋沁雯,王世丽,吕尚伶,陈晓芳,秦莹..2型糖尿病通过影响肠道菌群增加子痫前期的风险[J].国际医药卫生导报,2025,31(10):1586-1591,6.基金项目
山东省中医药科技项目(Z-2023075) Project of Science and Technology of Traditional Chinese Medicine in Shandong Province(z-2023075) （Z-2023075）
