国际医药卫生导报2025，Vol.31Issue(10)：1637-1640,4.DOI:10.3760/cma.j.cn441417-20241127-10011
艾司西酞普兰联合重复经颅磁刺激在卒中后抑郁患者中的疗效分析
Efficacy of escitalopram combined with repetitive transcranial magnetic stimulation for patients with post-stroke depression
摘要
Abstract
Objective To observe the therapeutic effect of escitalopram and repetitive transcranial magnetic stimulation for patients with post-stroke depression and the effect on their neurotransmitters.Methods This was a prospective study.Ninety patients with post-stroke depression who were admitted to Department of Neurology,Shenmu Hospital,Northwest University from February 2023 to March 2024 were selected as the study objects,and were divided into a study group and a control group by the random number table method,with 49 cases in each group.There were 21 males and 18 females in the study group;they were(58.31±4.26)years old.There were 22 males and 17 females in the control group;they were(58.82±4.17)years old.The control group took escitalopram once per day,10 mg per time;the study group took escitalopram and repetitive transcranial magnetic stimulation.Both groups were treated for 1 month.The treatment effective rates,scores of Hamilton Depression Rating Scale-17(HAMD-17)and modified Barthel index,and levels of neurotransmitter and were compared between the two groups.The independent-sample t and x2 tests were used for the statistical analysis.Results After one month's treatment,the total effective rate in the study group was higher than that in the control group[93.88％(46/49)vs.79.59％(39/49)];the scores of HAMD-17 and modified Barthel index in the study group were better than those in the control group(8.64±3.28 vs.11.13±3.37 and 63.81±3.27 vs.55.76±5.64);the levels of serotonin and norepinephrine in the study group were higher than those in the control group[(110.53±10.24)μg/L vs.(90.79±10.33)μg/L and(10.27±1.05)μg/L vs.(8.14±1.13)μg/L];there were statistical differences in the above indicators between the two groups(all P＜0.05).Conclusion Escitalopram combined with repetitive transcranial magnetic stimulation for patients with post-stroke depression can improve the treatment effective rate and their depression,daily life ability,and levels of neurotransmitters.关键词
卒中后抑郁/艾司西酞普兰/重复经颅磁刺激/神经递质Key words
Post-stroke depression/Escitalopram/Repetitive transcranial magnetic stimulation/Neurotransmitters引用本文复制引用
耿琳,罗奋阳,马现仓..艾司西酞普兰联合重复经颅磁刺激在卒中后抑郁患者中的疗效分析[J].国际医药卫生导报,2025,31(10):1637-1640,4.基金项目
国家自然科学基金(81171256) National Natural Science Foundation(81171256) （81171256）
