国际医药卫生导报2025，Vol.31Issue(10)：1641-1645,5.DOI:10.3760/cma.j.cn441417-20240827-10012
远端缺血适应联合依达拉奉右莰醇治疗急性脑梗死患者的效果
Remote ischemic conditioning combined with edaravone and dexamethasone for patients with acute cerebral infarction
摘要
Abstract
Objective To explore the effect of remote ischemic conditioning(RIC)combined with edaravone and dexamethasone for patients with acute cerebral infarction.Methods One hundred and sixty patients with acute cerebral infarction treated at The Third Affiliated Hospital of Xi'an Medical University between July 2021 and July 2023 were selected for the randomized controlled trial.The patients were divided into a control group and a study group by the random number table method,with 80 cases in each group.There were 41 males and 39 females in the control group;they were(63.37±7.48)years old.There were 46 males and 34 females in the study group;they were(62.59±6.97)years old.The control group were treated with edaravone and dexamethasone;in addition,the study group were treated with RIC.The total effective rates,incidence rates of adverse reactions,and levels of pro-inflammatory factors[tumor necrosis factor alpha(TNF-α),interleukin 1 beta(IL-1β),and interleukin 6(IL-6)],levels of S100 calcium-binding protein B(S100B),neurological function[scores of the Modified Rankin Scale(MRS)and the National Institutes of Health Stroke Scale(NIHSS)],and levels of neuroprotective factors[vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)]before and 2,4,12 weeks after the treatment were compared between the two groups.t and x2 tests were used for the statistical analysis.Results There was a statistical difference in the total effective rate between the study group and the control group[92.50％(74/80)vs.80.00％(64/80);P＜0.05].There was no statistical difference in the total effective rate between the study group and the control group[12.50％(10/80)and 10.00％(8/80);P＞0.05].After the treatment,the levels of TNF-α,IL-1β,S100B,and IL-6 were lower than those before the treatment in both groups,and the levels in the study group were lower than those in the control group(all P＜0.05).After the treatment,the levels of VEGF and BDNF were higher than those before the treatment in both groups,and the levels in the study group were higher than those in the control group(all P＜0.05).Conclusion RIC combined with edaravone and dexamethasone for patients with acute cerebral infarction is effective,and can improve their neurological function and prognosis.关键词
急性脑梗死/远端缺血适应/依达拉奉右莰醇/神经功能/促炎因子Key words
Acute cerebral infarction/Remote ischemic conditioning/Edaravone and dexamethasone/Neurological function/Inflammatory markers引用本文复制引用
周美宁,张玲如..远端缺血适应联合依达拉奉右莰醇治疗急性脑梗死患者的效果[J].国际医药卫生导报,2025,31(10):1641-1645,5.基金项目
陕西省自然科学基础研究计划(2023-JC-YB-797) Basic Research Plan of Natural Science in Shaanxi(2023-JC-YB-797) （2023-JC-YB-797）
