国际医药卫生导报2025，Vol.31Issue(10)：1670-1675,6.DOI:10.3760/cma.j.cn441417-20240311-10018
脑小血管病的多模态MRI及颈动脉超声指标与认知障碍的相关性
Correlation between multimodal MRI and carotid ultrasound indicators of cerebral small vessel disease and cognitive impairment
摘要
Abstract
Objective To explore of the diagnostic efficacy of multimodal magnetic resonance imaging(MRI)indicators and carotid ultrasound indicators for patients with cerebral small vessel disease and their correlation with cognitive impairment.Methods One hundred and ninety-five patients diagnosed with cerebral small vessel disease at Cardiovascular and Cerebrovascular Disease Hospital,Affiliated Hospital of Yan'an University from May 2020 to May 2023 were selected as the study objects.Based on the scores of the Montreal Cognitive Assessment Scale(MoCA),the patients were divided into a cognitive impairment(CL)group(106 cases)and a non-cognitive impairment(NCL)group(89 cases).If the MoCA score＜23,there is cognitive impairment.There were 56 males and 50 females in the CL group;they were(70.73±9.42)years old.There were 48 males and 41 females in the NCL group;they were(65.58±9.29)years old.The multimodal MRI parameters[white matter hyperintensities(WMH),lacunar infarcts(LI),cerebral microbleeds(CMBs),perivascular spaces(PVS),and brain atrophy]and carotid ultrasound markers(score of extracranial carotid atherosclerosis)were detected.The correlation of the multimodal MRI parameters and carotid ultrasound marker with cognitive impairment was analyzed by the Spearman correlation analysis.The diagnostic efficacy of these indicators for cerebral small vessel disease-related cognitive impairment was assessed using the receiver operating characteristic curve(ROC).t,x2,and Mann-Whitney U tests were used for the statistical analysis.Results All the neuroimaging indicators in the NCL group were lower than those in the CL group(all P＜0.05),including Fazekas score[2.00(1.00,2.00)vs.3.50(2.00,4.00)],number of LI[1.00(0.00,1.00)vs.2.00(1.00,3.00)],number of CMBs[1.00(0.00,1.00)vs.1.00(0.00,2.00)],CSO-PVS score[1.00(0.00,2.00)vs.1.00(1.00,2.00)],BG-PVS score[1.00(1.00,2.00)vs.1.00(1.00,2.00)],GCA score[1.00(1.00,2.00)vs.2.00(1.00,2.00)],and extracranial carotid atherosclerosis score[2.00(1.00,3.50)vs.4.00(3.00,4.00)].The correlation analysis showed that the Fazekas score,number of LI,number of CMBs,CSO-PVS score,BG-PVS score,GCA score,and score of extracranial carotid atherosclerosis were negatively correlated with the MoCA score(r=-0.372,-0.320,-0.241,-0.163,-0.182,-0.374,and-0.191;all P＜0.05).The area under the curve of the multimodal MRI parameters combined with the carotid ultrasound marker for diagnosing cognitive impairment in the patients with cerebral small vessel disease was 0.826(95％CI 0.764-0.888),with a sensitivity of 82.1％and a specificity of 83.1％.Conclusion There is a significant correlation of multimodal MRI and carotid ultrasound indicators with cognitive impairment in patients with cerebral small vessel disease.关键词
磁共振成像/颈动脉超声/脑小血管病/认知障碍Key words
Magnetic resonance imaging/Carotid ultrasound/Cerebral small vessel disease/Cognitive impairment引用本文复制引用
秦江彦,王涛,高任,范正..脑小血管病的多模态MRI及颈动脉超声指标与认知障碍的相关性[J].国际医药卫生导报,2025,31(10):1670-1675,6.基金项目
陕西省科协青年人才托举计划(20230315) Plan for Culturing Young Talents by Shaanxi Association of Science and Technology(20230315) （20230315）
