国际医药卫生导报2025，Vol.31Issue(10)：1713-1718,6.DOI:10.3760/cma.j.cn441417-20241220-10027
导赤散联合窄谱强脉冲光治疗寻常痤疮(心经积热证)临床研究
Daochi San combined with narrow-spectrum intense pulsed light for patients with acne vulgaris of heart meridian heat accumulation syndrome
摘要
Abstract
Objective To explore the effect of Daochi San combined with narrow-spectrum intense pulsed light for patients with acne vulgaris of heart meridian heat accumulation syndrome.Method A total of 126 patients with acne vulgaris admitted to Chang'an Hospital from January 2022 to July 2024 were selected as the prospective research subjects,and were divided into a Daochi San group,narrow-spectrum intense pulsed light group,and a combination group by lottery,with 42 patients in each group.There were 15 males and 27 females in the Daochi San group,with an age of(23.67±4.66)years and a disease course of(1.48±0.31)years.There were 18 males and 24 females in the narrow-spectrum intense pulsed light group,with an age of(22.19±3.52)years and a disease course of(1.43±0.36)years.There were 16 males and 26 females in the combination group,with an age of(22.52±3.49)years and a disease course of(1.57±0.38)years.The Daochi San group were treated with the Daochi San,the narrow-spectrum intense pulsed light group narrow-spectrum intense pulsed light,and the combination group with Daochi San and narrow-spectrum intense pulsed light,for 3 months.The study evaluated traditional Chinese medicine symptom scores,skin lesion severity,serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-12(IL-12),and interleukin-17(IL-17)]before and after treatment,clinical efficacy,and adverse reaction incidence.One-way analysis of variance,t test,and x2 test were used for the statistical analysis.Results Before the treatment,there were no statistical differences in the scores of traditional Chinese medicine symptoms and skin lesions and levels of TNF-α,IL-12,and IL-17 between the 3 groups(all P＞0.05).After the treatment,the scores of traditional Chinese medicine symptoms(7.88±1.57,7.36±1.44,and 4.81±0.98)and skin lesion(10.38±2.34,9.52±2.08,and 6.05±0.98)and levels of TNF-α[(33.16±4.41)μg/L,(34.53±4.78)μg/L,and(27.84±3.66)μg/L],IL-12[(30.34±3.85)μg/L,(29.22±3.34)μg/L,and(23.65±3.09)μg/L],and IL-17[(1.42±0.26)μg/L,(1.37±0.25)μg/L,and(0.92±0.18)μg/L]decreased in the three groups(all P＜0.001),and there were statistical differences between the 3 groups(all P＜0.001);those in the combination group were lower than those in the Daochi San group(all P＜0.001)and those in the narrow-spectrum intense pulsed light group(all P＜0.001).The total effective rates of the Daochi San group,the narrow-spectrum intense pulsed light group,and the combination group were 69.05％(29/42),73.81％(31/42),and 92.86％(39/42),the combination group was higher than those in the Daochi San group and the narrow-spectrum intense pulsed light group(x2=7.919,P=0.0219).The incidence rates of adverse reactions in the Daochi San group,the narrow-spectrum intense pulsed light group,and the combination group were 2.38％(1/42),7.14％(3/42),and 9.52％(4/42),respectively,with no statistical difference(x2=1.869,P＞0.05).Conclusion Daochi San combined with narrow-spectrum intense pulsed light for patients with acne vulgaris of heart meridian heat accumulation syndrome can promote symptom relief and skin lesion regression,inhibit inflammatory reactions,with high efficacy and good safety.关键词
寻常痤疮/心经积热证/导赤散/窄谱强脉冲光Key words
Acne vulgaris/Heart meridian heat accumulation syndrome/Daochi San/Narrow-spectrum intense pulsed light引用本文复制引用
王少博,李伟,赵婵,刘燕..导赤散联合窄谱强脉冲光治疗寻常痤疮(心经积热证)临床研究[J].国际医药卫生导报,2025,31(10):1713-1718,6.基金项目
陕西省重点研发计划(S2024-YF-YBSF-1732) Key Plan of Research and Development in Shaanxi Province(S2024-YF-YBSF-1732) （S2024-YF-YBSF-1732）
