国际医药卫生导报2025，Vol.31Issue(10)：1724-1728,5.DOI:10.3760/cma.j.cn441417-20240605-10029
胎宝汤联合地屈孕酮治疗黄体功能不全性先兆流产患者的效果
Effect of Taibao Tang combined with dydrogesterone for patients with with threatened miscarriage due to luteal insufficiency
摘要
Abstract
Objective To investigate the effect of Taibao Tang combined with dydrogesterone for patients with threatened miscarriage due to luteal insufficiency and its impact on their endocrine and immune parameters.Methods This study was a prospective clinical controlled trial.Eighty-six patients with threatened miscarriage due to luteal insufficiency treated at Yulin Traditional Chinese Medicine Hospital from April 2021 to March 2023 were selected,and were divided into a control group and a study group by the random number table method,with 43 cases in each group.The study group were(29.39±4.48)years old and(8.93±2.11)weeks pregnant.The control group were(28.89±4.35)years old and(9.10±2.12)weeks pregnant.The control group took dydrogesterone,and the treatment group dydrogesterone and Taibao Tang.The scores of traditional Chinese medicine(TCM)syndrome,pregnancy maintenance rates,endocrine levels[serum progesterone(P),estradiol(E2),and human chorionic gonadotropin(β-hCG)],immune parameters(CD4+,CD8+,and CD4+/CD8+ratio),and pregnancy outcomes were compared between the two groups.t and x2 tests were used for the statistical analysis.Results After the treatment,the time for the disappearance of abdominal pain,time for vaginal hemostasis,and score of TCM syndromes in the study group were lower than those in the control group[(2.17±0.51)d vs.(2.53±0.49)d,(2.19±0.40)d vs.(2.48±0.47)d,5.32±1.13 vs.6.23±1.07],with statistical differences(t=3.338,3.081,and 3.834;all P＜0.05).After the treatment,the scores of P,E2,and β-hCG in the study group were higher than those in the control group[(48.67±6.30)μg/L vs.(45.16±6.23)μg/L,(638.23±39.18)ng/L vs.(616.06±43.28)ng/L,and(8 536.88±365.02)IU/L vs.(8 343.15±371.29)IU/L],with statistical differences(all P＜0.05).After the treatment,the levels of CD4+,CD4+/CD8+,CD8+in the study group were better than those in the control group(35.55±3.61 vs.37.27±4.10,1.26±0.33 vs.1.48±0.32,28.24±3.82 vs.26.16±4.01),with statistical differences(t=2.065,3.138,and 2.463;all P＜0.05).There was no statistical differencein the incidence rate of adverse reactions between the study group and the control group[9.30％(4/43)vs.13.95％(6/43);x2=0.453;P＞0.05].The newborns' body weight in the study group was higher than that in the control group[(2 530.32±268.41)g vs.(2 423.31±223.26)g],with a statistical difference(t=2.010;P＜0.05).Conclusion Taibao Tang combined with dydrogesterone in the treatment of patients with with threatened miscarriage due to luteal insufficiency can improve their endocrine levels,immune function,and treatment effect,and reduce the risk of miscarriage.关键词
黄体功能不全/先兆流产/胎宝汤/地屈孕酮/内分泌/免疫功能Key words
Luteal insufficiency/Threatened miscarriage/Taibao Tang/Dydrogesterone/Endocrine/Immune function引用本文复制引用
窦娜,刘筱茂,李春春,张媛,霍艳宁,冯艳霞..胎宝汤联合地屈孕酮治疗黄体功能不全性先兆流产患者的效果[J].国际医药卫生导报,2025,31(10):1724-1728,5.基金项目
陕西省中医药管理局项目(SZY-NLTL-2022-027) Project of Traditional Chinese Medicine Administration of Shaanxi Province(SZY-NLTL-2022-027) （SZY-NLTL-2022-027）
