国际医学放射学杂志2025，Vol.48Issue(3)：263-269,7.DOI:10.19300/j.2025.L21378
基于纤维束示踪的空间统计方法对系统性红斑狼疮病人脑微结构改变的研究
A study on brain microstructural changes in systemic lupus erythematosus patients using tract-based spatial statistics
摘要
Abstract
Objective To investigate differences in white matter microstructure between patients with neuropsy-chiatric systemic lupus erythematosus(NPSLE)and those with non-neuropsychiatric SLE(Non-NPSLE)using tract-based spatial statistics(TBSS).Methods A total of 34 NPSLE patients and 32 Non-NPSLE patients were prospectively enrolled,along with 33 healthy controls(HC)during the same period.All participants underwent brain diffusion tensor imaging(DTI).TBSS was used to compare white matter microstructural differences among the three groups.Fractional anisotropy(FA)values were compared using one-way ANOVA,with post hoc analyses conducted for pairwise group comparisons.Partial correlation analyses assessed the relationships between FA values of significantly different clusters and neuropsychological scores or clinical indicators,as well as the correlations between neuropsychological scores and clinical indicators.Results Five clusters showed significant FA differences among the three groups(P<0.05,FWE-corrected).Post hoc analysis revealed that two clusters in both the Non-NPSLE and NPSLE groups had lower FA values than the HC group,and one cluster in the NPSLE group had a lower FA value than the Non-NPSLE group(P<0.05,FWE-corrected),indicating more extensive white matter involvement in NPSLE.FA reductions in SLE patients were primarily located in the corpus callosum and corona radiata.Correlation analysis showed that FA values of the significant clusters in pairwise comparisons were positively correlated with IgM levels(P<0.05).In the NPSLE group,HADS-D scores were negatively correlated with C4 levels(r=-0.354,P=0.047),while in the Non-NPSLE group,MoCA scores were negatively correlated with ESR(r=-0.424,P=0.019).Conclusion NPSLE patients exhibit more extensive white matter microstructural damage compared to Non-NPSLE patients.The FA values of some differential clusters correlate with clinical indicators,suggesting that these changes may serve as important imaging biomarkers for detecting disease activity or neuropsychiatric involvement in SLE.关键词
系统性红斑狼疮/磁共振成像/扩散张量成像/各向异性分数Key words
Systemic lupus erythematosus/Magnetic resonance imaging/Diffusion tensor imaging/Fractional anisotropy分类
临床医学引用本文复制引用
孙中茹,夏建国,李一凡,王宁,田为中,邹红梅..基于纤维束示踪的空间统计方法对系统性红斑狼疮病人脑微结构改变的研究[J].国际医学放射学杂志,2025,48(3):263-269,7.基金项目
江苏省卫生健康委科研项目(H2018093) （H2018093）
江苏省第五期"333工程"科研项目(BRA2017175) （BRA2017175）
