国际医学放射学杂志2025，Vol.48Issue(3)：270-276,7.DOI:10.19300/j.2025.L21464
感觉神经性耳聋局部自发脑活动异常的静息态功能MRI激活似然估计荟萃分析
Resting-state functional MRI activation likelihood estimation meta-analysis of abnormal spontaneous brain activity in sensorineural hearing loss
摘要
Abstract
Objective To investigate the characteristics of altered spontaneous brain activity in patients with sensorineural hearing loss(SNHL)using activation likelihood estimation(ALE)meta-analysis,and to further understand the potential neural mechanisms of brain functional impairment and remodeling in SNHL.Methods A systematic search was conducted up to August 21,2023,in Web of Science,PubMed,CNKI,Wanfang Med Online,and the Chinese Medical Journal Full-text Database for studies applying regional homogeneity(ReHo)and amplitude of low-frequency fluctuation/fractional ALFF(ALFF/fALFF)analyses to evaluate brain functional changes in SNHL patients.After applying inclusion and exclusion criteria,studies were included in a meta-analysis using the ALE method to identify brain regions with abnormal spontaneous neural activity in SNHL patients.Results A total of 22 articles comprising 29 studies were included,involving 736 cases of SNHL and 487 controls.Among these,11 studies used ReHo and 18 studies used ALFF/fALFF.A combined analysis of ReHo/ALFF/fALFF without differentiating the side of deafness revealed increased spontaneous brain activity in the left medial dorsal thalamus,and decreased activity in the left superior temporal gyrus,left opercular part of the inferior frontal gyrus,and left dorsolateral prefrontal cortex.Separate ALE analyses for left-sided and right-sided SNHL patients,as well as separate analyses using ReHo or ALFF/fALFF methods,did not identify any significantly altered brain regions.Conclusion The ALE meta-analysis confirms that SNHL patients exhibit abnormal spontaneous activity in multiple brain regions.These findings help elucidate the patterns and characteristics of brain functional damage and remodeling associated with SNHL,providing important evidence for future clinical assessment and treatment planning.关键词
感觉神经性耳聋/静息态功能磁共振成像/激活似然估计法/自发脑活动Key words
Sensorineural hearing loss/Resting state functional magnetic resonance imaging/Activation likelihood estimation/Spontaneous brain activity分类
临床医学引用本文复制引用
王爱杰,黄冉冉,王春业,李韵昕,包相华,张国伟..感觉神经性耳聋局部自发脑活动异常的静息态功能MRI激活似然估计荟萃分析[J].国际医学放射学杂志,2025,48(3):270-276,7.基金项目
山东省医药卫生科技项目(202409040614) （202409040614）
