国际医学放射学杂志2025，Vol.48Issue(3)：277-284,8.DOI:10.19300/j.2025.L21953
冠状动脉周围脂肪衰减指数变化与斑块进展的相关性分析
Correlation analysis between changes in pericoronary fat attenuation index and plaque progression
摘要
Abstract
Objective To investigate the relationship between pericoronary fat attenuation index(FAI)and the plaque progression.Methods This retrospective study included 140 inpatients with suspected coronary artery disease(CAD)who underwent consecutive coronary computed tomography angiography(CCTA),with an average age of 56.8±10.5 years old.A total of 348 plaques were identified.Clinical data,as well as baseline and follow-up(at least one year apart)CCTA imaging data,were collected.Characteristics,degree of stenosis,plaque volume(PV),and percentage atheroma volume(PAV)were analyzed.Peri-plaque FAI was measured and analyzed.A multivariate generalized estimating equation was used to adjust for confounding variables,and linear regression models were fitted to analyze the association between the annual change in FAI(ΔFAI/y)and the annual changes in PV(ΔPV/y)and PAV(ΔPAV/y).Results The median interval between the two CCTA scans was 2.3(1.7,3.8)years.Quantitative analysis of the two scans revealed significant increases in all components of PV and PAV except for lipid PV and lipid PAV(all P<0.001).After adjusting for China-PAR score,Leiden score,TyG index,antiplatelet therapy,and statin use using generalized estimating equation,ΔPAV/y of total plaques was significantly positively correlated with ΔFAI/y(β=0.156,95%CI:0.025-0.287,P=0.019).Specifically,ΔPAV/y of non-calcified plaques(β=0.139,95%CI:0.006-0.273,P=0.041)and fibrous plaques(β=0.197,95%CI:0.067-0.327,P=0.003)also showed significant positive correlations with ΔFAI/y.Conclusion Changes in FAI are consistent with changes in non-calcified PAV and fibrous PAV.This may help identify potentially high-risk patients with stable coronary artery disease and supports the use of FAI as a valuable tool for evaluating treatment efficacy in coronary artery disease.关键词
冠状动脉粥样硬化/心脏病/CT血管成像/体层摄影术,X线计算机/脂肪组织衰减指数/斑块Key words
Coronary atherosclerosis/Heart disease/Computed tomography angiography/Tomography,X-ray computed/Fat attenuation index/Plaque分类
特种医学引用本文复制引用
陈冠熹,郭自强,宋珊,党霆钰,杨钊,王玺,刘子暖,杨俊杰..冠状动脉周围脂肪衰减指数变化与斑块进展的相关性分析[J].国际医学放射学杂志,2025,48(3):277-284,8.基金项目
国家重点研发计划项目(2021YFC2500505) （2021YFC2500505）
国家自然科学基金(82470342) （82470342）
北京市科技新星计划项目(20230484471) （20230484471）
