广西医学2025，Vol.47Issue(3)：382-387,6.DOI:10.11675/j.issn.0253-4304.2025.03.09
健脾益肾方联合CAG方案治疗老年急性髓系白血病的临床效果
Clinical effect of Jianpi Yishen Prescription combined with CAG regimen for the treatment of elderly acute myeloid leukemia
摘要
Abstract
Objective To explore the effectiveness and safety of Jianpi Yishen Prescription combined with CAG regimen,namely,cytarabine plus aclarubicin plus recombinant human granulocyte colony-stimulating factor,for the treatment of elderly acute myeloid leukemia(AML).Methods A total of 132 elderly AML patients were randomly divided into control group or observation group,with 66 cases in each group.The control group received CAG regimen for treatment,based on which the observation group received Jianpi Yishen Prescription for treatment.The blood routine,blood biochemical indices with respect to serum ALT,AST,β2-microglobulin,lactate dehydrogenase,creatinine,urea nitrogen levels and quality of life before and after treatment,as well as post-treatment clinical efficacy,blood transfusion volume during treatment(transfusion volume of red blood cell suspension,transfusion volume of platelet)and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the observation group was higher than that in the control group,and the transfusion volumes of red blood cell suspension and platelet were lower than those in the control group(P<0.05).After treatment,patients of both groups obtained higher white cell counts,neutrophil counts,blood platelet counts,reticulocyte counts,and higher levels of serum ALT,AST,creatinine,as well as higher quality of life as compared with before treatment,whereas lower hemoglobin,serum β2-microglobulin and lactate dehydrogenase levels as compared with before treatment.Among which the observation group exhibited higher white cell counts,neutrophil counts,blood platelet counts,reticulocyte counts,and higher levels of serum AST,creatinine,and urea nitrogen,whereas lower levels of hemoglobin,serum ALT,β2-microglobulin,and lactate dehydrogenase as compared with the control group(P<0.05).There was no statistically significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Jianpi Yishen Prescription combined with CAG regimen for the treatment of elderly AML patients can improve their clinical efficacy and quality of life,relieve response to hematological toxicity,with a favorable safety.关键词
急性髓系白血病/老年人/健脾益肾方/化疗/中西医结合/临床疗效/安全性Key words
Acute myeloid leukemia/The elderly/Jianpi Yishen Prescription/Chemotherapy/Integrated Traditional Chinese and Western Medicine/Clinical efficacy/Safety分类
临床医学引用本文复制引用
单金璇,李伟,高彩凤,高雅君,张新荣..健脾益肾方联合CAG方案治疗老年急性髓系白血病的临床效果[J].广西医学,2025,47(3):382-387,6.基金项目
河北省中医药管理局中医药类科研计划课题(2022572) （2022572）
