Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation
Mohammad Alhashmi Ke Liu Maria M.Meschis Hazel Sutherland Peter Wilson Peter Clegg Grant N.Wheeler Robert J.van't Hof George Bou-Gharios Kazuhiro Yamamoto Abdulrahman M.E.Gremida Santosh K.Maharana Marco Antonaci Amy Kerr Shijian Fu Sharna Lunn David A.Turner Noor A.Al-Maslamani
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation
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Mohammad Alhashmi,Ke Liu,Maria M.Meschis,Hazel Sutherland,Peter Wilson,Peter Clegg,Grant N.Wheeler,Robert J.van't Hof,George Bou-Gharios,Kazuhiro Yamamoto,Abdulrahman M.E.Gremida,Santosh K.Maharana,Marco Antonaci,Amy Kerr,Shijian Fu,Sharna Lunn,David A.Turner,Noor A.Al-Maslamani..Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation[J].骨研究（英文版）,2025,13(2):384-400,17.基金项目
We would like to thank Dr Steven Allen(Royal Veterinary College)for TOPFlash luciferase assay vectors,Professor Andrew Pitsillides(Royal Veterinary College),Professor Philippa Francis-West(Kings College London),Professor Dudley Strickland(University of Maryland School of Medicine),Dr Salvatore Santamaria(University of Surrey),Professor Terence Capellini(Harvard University)and Dr Kathryn Scott for helpful discussions during the writing of this manuscript.The Authors are grateful to the staff at the Biomedical Services,the Histology Units,the Centre for Preclinical Imaging and the Centre for Cell Imaging(CCI)facilities provided by Liverpool Shared Research Facilities,Faculty of Health and Life Sciences,University of Liverpool.The Andor dragonfly Spinning Disk microscope in the CCI was funded by the BBSRC(BB/R01390X/1).This work was supported by the ministry of education of the Kingdom of Saudi Arabia(to M.Alhashmi),Libyan Ministry of Higher Education and Scientific Research and ECMage(to A.M.E.Gremida),Qatar National Research Fund(to N.A.Al-Maslamani),European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement(860635 to M.Antonaci and A.Kerr),BBSRC Grants(BB/T00715X/1 to S.K.Maharana and G.N.Wheeler （Royal Veterinary College）
BB/X000907/1 to D.A.Turner),Versus Arthritis Career Development Fellowship(21447 to K.Yamamoto)and Versus Arthritis Bridging Fellowship(23137 to K.Yamamoto). （21447 to K.Yamamoto）
