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Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction

Haoran Xu Fengxian Jiang Jun Wang Lei Sheng Jun Dai Kang Wei Jinhao Ni Xiaofeng Deng Yuexing Wang Taiyang Xiang Fanglong Song Qianliang Wang Yanping Niu

骨研究（英文版）2025，Vol.13Issue(2)：476-489,14.

骨研究（英文版）2025，Vol.13Issue(2)：476-489,14.DOI:10.1038/s41413-025-00402-7

Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction

Haoran Xu ¹Fengxian Jiang ²Jun Wang ³Lei Sheng ²Jun Dai ²Kang Wei ⁴Jinhao Ni ²Xiaofeng Deng ⁵Yuexing Wang ²Taiyang Xiang ²Fanglong Song ²Qianliang Wang ²Yanping Niu²

作者信息

1. Department of Orthopedic Surgery,The Second Affiliated Hospital of Soochow University,Suzhou,China||Department of Orthopedic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
2. Department of Orthopedic Surgery,The Second Affiliated Hospital of Soochow University,Suzhou,China
3. State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,China
4. Department of Plastic Surgery,Zhongnan Hospital of Wuhan University,Wuhan,China
5. Department of Rehabilitation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
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摘要

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Haoran Xu,Fengxian Jiang,Jun Wang,Lei Sheng,Jun Dai,Kang Wei,Jinhao Ni,Xiaofeng Deng,Yuexing Wang,Taiyang Xiang,Fanglong Song,Qianliang Wang,Yanping Niu..Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction[J].骨研究（英文版）,2025,13(2):476-489,14.

基金项目

This work was supported by the National Nature Science Foundation of China(No.82002345 to J.D and 81902179 to L.S),the Gusu Talent Program(No.Qngg2022008 and GSWS2021027 to J.D),and the Preliminary Research Project of the Second Affiliated Hospital of Soochow University(No.SDFEYBS1905 to J.D). （No.82002345 to J.D and 81902179 to L.S）

骨研究（英文版）

ISSN：2095-4700

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