海南医科大学学报2025，Vol.31Issue(9)：702-709,8.DOI:10.13210/j.cnki.jhmu.20250102.004
细胞的训练免疫在免疫疾病中的作用及进展
The role and progress of trained immunity of cells in immune diseases
摘要
Abstract
Researches have found that innate immune cells exhibit enhanced or attenuated responses upon re-encountering with infection,following stimulation by pathogenic microorganisms and their products.This phenomenon is defined as trained im-munity.The introduction of this concept challenges the traditional belief that only adaptive immunity possesses immune memory.Trained immunity differs from adaptive immune memory in terms of participating cell types,response specificity,and duration.This article provides a comprehensive review of the characteristics of trained immunity,the mechanisms underlying its generation,and its role in immune-related diseases,for the purpose of offering important theoretical support to future exploration of new treat-ment methods for immune-related diseases and aiding in the development of related drugs within an academic context.关键词
训练免疫/固有免疫/表观遗传重编程/免疫性疾病Key words
Trained immunity/Intrinsic immunity/Epigenetic reprogramming/Immune diseases分类
基础医学引用本文复制引用
袁润达,卢芳,刘树民,于栋华..细胞的训练免疫在免疫疾病中的作用及进展[J].海南医科大学学报,2025,31(9):702-709,8.基金项目
This study was supported by the National Natural Science Foundation of China(82074149)and Natural Science Foundation Project of Heilongjiang Province(PL2024H242) 国家自然科学基金资助项目(82074149) （82074149）
黑龙江省自然科学基金资助项目(PL2024H242) （PL2024H242）
