海南医科大学学报2025，Vol.31Issue(9)：710-720,11.DOI:10.13210/j.cnki.jhmu.20250115.001
铁自噬与线粒体自噬在缺血性脑卒中中的研究进展
Advances in ferritinophagy and mitophagy in ischemic stroke
摘要
Abstract
Ischemic stroke is a group of clinical syndromes in which cerebral ischemic and hypoxic injury occurs due to blood supply disorders,and then neurological dysfunction occurs.Selective autophagy refers to the process by which autophagosomes specifically degrade substrates by fusing with lysosomes to maintain cellular homeostasis.Increasing evidence suggests that selec-tive autophagy is involved in regulating neuronal damage caused by energy consumption,oxidative stress,and inflammation fol-lowing ischemic stroke.This article reviews the mechanisms of selective autophagy,such as ferritinophagy and mitophagy,which play a predominant role in ischemic stroke,as well as the therapeutic effects of drug intervention targeting ferritinophagy and mi-tophagy in ischemic stroke,providing a theoretical basis for exploring new integrated Chinese and Western medicine approaches for neuroprotection after ischemic stroke.关键词
缺血性脑卒中/选择性自噬/铁自噬/线粒体自噬Key words
Ischemic stroke/Selective Autophagy/Ferritinophagy/Mitophagy分类
医药卫生引用本文复制引用
杜秋思,刘丹红,韦梦真,廖君..铁自噬与线粒体自噬在缺血性脑卒中中的研究进展[J].海南医科大学学报,2025,31(9):710-720,11.基金项目
This study was supported by Natural Science Foundation of Hunan Province(2021JJ30946) （2021JJ30946）
Key Project of Hunan Provincial Department of Education(20A362) （20A362）
Key Guiding Project of Hunan Provincial Administration of Traditional Chinese Medicine(202303) （202303）
Graduate Student Innovation Project of Hunan University of Chinese Medicine(2023CX161) 湖南省自然科学基金(2021JJ30946) （2023CX161）
湖南省教育厅重点课题(20A362) （20A362）
湖南省中医药管理局重点指导课题(202303) （202303）
湖南中医药大学研究生创新课题(2023CX161) （2023CX161）
