化工进展2025，Vol.44Issue(5)：2407-2420,14.DOI:10.16085/j.issn.1000-6613.2024-2127
靶向治疗蛋白与肽的工程化设计优化及应用进展
Advances in engineering design,optimization and application of targeted therapeutic proteins and peptides
摘要
Abstract
Targeted therapeutic proteins and peptides are playing an increasingly important role in precision medicine,especially in the treatment of cancer and immune diseases,showing significant potential.Compared with traditional small molecule drugs,targeted proteins and peptides have higher specificity and lower side effects,and can accurately target disease-related molecules.However,their clinical application still faces a series of challenges,such as poor stability,high immunogenicity,and poor pharmacokinetics.In order to overcome these challenges,engineering design optimization has become the key to improving their efficacy,safety and clinical application prospects.This article firstly introduces the steps of engineering design of targeted therapeutic proteins and peptides,briefly describes the optimization design methods of peptide drugs and protein drugs,explores related drug delivery strategies and lists some drug examples,and analyzes the current clinical application status,challenges and development prospects of targeted therapy proteins and peptides.Finally,it is pointed out that with the continuous development of technology,targeted therapeutic proteins and peptides will play a more important role in precision medicine and provide more efficient treatments for a variety of complex diseases.关键词
靶向性治疗/蛋白质/单克隆抗体/生物分子工程/精准医学Key words
targeted therapy/protein/monoclonal antibody/biomolecular engineering/precision medicine分类
生物工程引用本文复制引用
江奇逸,邓鑫月,袁艳婷,张雅倩,杨敏,李伟娜,范代娣..靶向治疗蛋白与肽的工程化设计优化及应用进展[J].化工进展,2025,44(5):2407-2420,14.基金项目
国家自然科学基金(22378330). （22378330）
