化工进展2025，Vol.44Issue(5)：2421-2428,8.DOI:10.16085/j.issn.1000-6613.2024-1846
基于嗜盐底盘的可再生资源利用与生物制造
Renewable source utilization and biomanufacturing based on halophilic chassis
摘要
Abstract
Enhancing the sustainability of production processes under the leadership of the"carbon neutrality"initiative,there is a growing shift from fossil fuel-dependent methods to biomanufacturing practices that are both sustainable and environmentally friendly.Halophilic microorganisms,which flourish in high-salt environments,are emerging as key chassis in biomanufacturing due to their distinctive benefits.Notably,Halomonas bluephagenesis(H.bluephagenesis)stands out for its ability to synthesize a range of biodegradable bioplastics,specifically polyhydroxyalkanoates(PHA),through open and continuous fermentation processes.This microorganism's capacity to convert low-cost substrates or waste materials into high-value products significantly bolsters the viability of sustainable biomanufacturing.Advancements in genetic engineering and metabolic pathway optimization,along with morphological engineering tailored for H.bluephagenesis,have led to substantial reductions in the production costs of a diverse array of polymers,small molecules,amino acids,and proteins.This paper further discusses the strategic utilization of cost-effective carbon sources,such as starch,cellulose,acetic acid,and food waste,as substrates for halophilic microorganisms to produce valuable compounds.Finally,it also examines the potential and prospective applications of H.bluephagenesis in harnessing one-carbon compounds for biomanufacturing,which is crucial for the development of next-generation industrial biotechnology and the realization of carbon neutrality goals.关键词
嗜盐微生物/下一代工业生物技术/聚羟基脂肪酸酯/可再生能源/碳中和Key words
halophile/next generation industrial biotechnology(NGIB)/polyhydroxyalkanoates/renewable source/carbon neutrality分类
化学工程引用本文复制引用
王婉泽,丁军,闫煦,陈国强..基于嗜盐底盘的可再生资源利用与生物制造[J].化工进展,2025,44(5):2421-2428,8.基金项目
国家自然科学基金(32130001). （32130001）
