化工进展2025，Vol.44Issue(5)：2429-2440,12.DOI:10.16085/j.issn.1000-6613.2024-2057
化学-生物级联转化CO2合成单细胞蛋白研究进展
Progress in cascade conversion of CO2 to single cell protein through chemical and biological catalysis
摘要
Abstract
As the development of industry,a large amount of CO2 emissions has aggravated greenhouse effect of the world and environmental pollution.In addition,the growing global population will face the problem of insufficient supply of protein resources.A more efficient route for CO2 fixation and conversion involves chemical reduction of CO2 to synthesize methanol,followed by microbial conversion of methanol into multi-carbon products.Therefore,from both a feedstock and product perspective,this review suggests the use of a chemical-biological cascade process for CO2 conversion to produce single-cell protein(SCP),which involves the chemical reduction of CO2 to methanol,followed by the microbial production of SCP from methanol and ammonium using microbial cell factories.The SCP from CO2 can be used in the feed and food industries.Firstly,the reaction processes,mechanisms,and catalyst design for the sustainable hydrogenation of CO2 to methanol are introduced.Secondly,methanol-utilizing microorganisms found in the nature,their methanol metabolic pathways,and their application in converting methanol into SCP are summarized.Finally,the bottlenecks and potential solutions for the industrial-scale production of SCP via chemical-biological cascade conversion of CO2 are prospected.关键词
一碳化工/甲醇/级联转化/单细胞蛋白/微生物细胞工厂Key words
one-carbon chemical engineering/methanol/cascade conversion/single cell protein/microbial cell factory分类
化学化工引用本文复制引用
吴孟勤,王佳瑶,徐友强,王钰..化学-生物级联转化CO2合成单细胞蛋白研究进展[J].化工进展,2025,44(5):2429-2440,12.基金项目
国家重点研发计划(2024YFA0918100) （2024YFA0918100）
天津市自然科学基金(24JCJQJC00010). （24JCJQJC00010）
