化工进展2025，Vol.44Issue(5)：2451-2462,12.DOI:10.16085/j.issn.1000-6613.2024-1841
甲基杆菌有效同化工业甲醇和植物甲醇的研究进展
Recent advances in strengthening Methylobacterium chassis for the utilization of methanol from industrial and plant sources
摘要
Abstract
Methanol is a significant raw material for third-generation industrial biomanufacturing and is also released into the atmosphere during plant growth,contributing to the greenhouse effect.Methylobacterium is a type of strain with broad application prospects and can use methanol as a carbon source and energy for growth.However,the catalytic conversion process of high-concentration industrial methanol and low-concentration plant methanol by Methylobacterium exhibits low efficiency,which results in the unnecessary dissipation of methanol's carbon and electrons,thereby limiting the high-value utilization of methanol.This article presents a systematic review of the latest strategies for enhancing the effective metabolism of industrial methanol through chassis remodeling of Methylobacterium.It subsequently discusses current insights into Methylobacterium's effective oxidation,assimilation,and conversion of low-concentration methanol derived from plant sources.Finally,this review explores potential research directions and strategies for further enhancing methanol utilization by Methylobacterium.Its objectives include promoting scientific research and technology innovation on Methylobacterium as a methanol-based cellular factory and a novel plant probiotic agent.This supports the high-value utilization of methanol in industrial biotechnology,enhances the fixation and sequestration of plant-derived methanol,and aims to achieve a win-win solution strategy for both economic and eco environmental benefits.关键词
甲基杆菌/甲醇/甲基细胞工厂/植物叶际益生菌/合成生物技术Key words
Methylobacterium/methanol/methylotrophic cell factory/plant phyllospheric probiotics/synthetic biotechnology分类
生物工程引用本文复制引用
姚陆,马增新,张聪,杨松,邢新会..甲基杆菌有效同化工业甲醇和植物甲醇的研究进展[J].化工进展,2025,44(5):2451-2462,12.基金项目
国家重点研发计划(2021YFC2103500) （2021YFC2103500）
国家自然科学基金(22078169,22478217) （22078169,22478217）
国家自然科学基金青年基金(31900004,32000003). （31900004,32000003）
