化工进展2025，Vol.44Issue(5)：2811-2824,14.DOI:10.16085/j.issn.1000-6613.2024-1982
以CO2为原料的第三代生物炼制现状
Current status of the third-generation carbon-one biorefinery using CO2 as raw material
摘要
Abstract
The microbial fermentation of one-carbon(C1)gases to produce biofuels and chemicals represents a key pathway for carbon resource capture,utilization,and green biomanufacturing.One-carbon feedstocks,such as CO,CO2,methane,methanol,and formic acid,are characterized by their single-carbon atom composition.These resources are abundant,low-cost,and hold potential as alternative feedstocks for biomanufacturing.Additionally,their bioconversion contributes to mitigating the greenhouse effect and supports the achievement of carbon neutrality goals.This article reviews recent progress in microbial refining of CO2 to produce essential organic acids and alcohols,elaborates on the biological metabolic pathways of CO2 and product synthesis,discusses the genetic engineering of microorganisms in C1 biorefining,and envisions future pathways for green biomanufacturing.关键词
一碳气体/生物炼制/固碳途径/代谢工程Key words
one carbon/bio-refinery/carbon fixation/metabolic engineering分类
生物科学引用本文复制引用
李煜真,贺铭敬,王皓明,马小清,刘立成,李福利..以CO2为原料的第三代生物炼制现状[J].化工进展,2025,44(5):2811-2824,14.基金项目
国家自然科学基金联合基金重点项目(U22A20425). （U22A20425）
