湖南中医药大学学报2025，Vol.45Issue(4)：748-752,5.DOI:10.3969/j.issn.1674-070X.2025.04.025
从"脾失散精、毒邪内生"理论与线粒体自噬介导铁死亡探讨溃疡性结肠炎病机
Exploring the pathogenesis of ulcerative colitis based on the theory of"spleen deficiency leading to dysfunction of essence distribution and endogenous toxic pathogens"and mitophagy-mediated ferroptosis
摘要
Abstract
Chinese medicine posits that"spleen deficiency leading to dysfunction of essence distribution and endogenous toxic pathogens"is the pathogenesis of chronic diarrhea,which is analogous to ulcerative colitis(UC)caused by mitophagy-mediated ferroptosis.Based on the TCM theory of"analogy and imagery","spleen deficiency leading to dysfunction of essence distribution"corresponds to cellular energy deficiency resulting from mitophagy,while"endogenous toxic pathogens"are akin to inflammatory reaction triggered by ferroptosis.Therefore,this paper aims to explore the mechanism of action of TCM in regulating mitophagy-mediated ferroptosis for the treatment of UC,based on the theory of"spleen deficiency leading to dysfunction of essence distribution and endogenous toxic pathogens".Furthermore,it has provided an in-depth analysis of the interplay among mitophagy,ferroptosis,and UC,offering a reliable basis and novel therapeutic insights for the modernization of TCM research.关键词
溃疡性结肠炎/脾失散精/毒邪内生/线粒体自噬/铁死亡/氧化应激Key words
ulcerative colitis/spleen deficiency leading to dysfunction of essence distribution/endogenous toxic pathogens/mitophagy/ferroptosis/oxidative stress分类
医药卫生引用本文复制引用
武迎香,牛明了,张龙江,甄欢欢,齐云菲,陈敏迪..从"脾失散精、毒邪内生"理论与线粒体自噬介导铁死亡探讨溃疡性结肠炎病机[J].湖南中医药大学学报,2025,45(4):748-752,5.基金项目
河南省中医药科学研究专项课题(2023ZY2083). （2023ZY2083）
