华侨大学学报（自然科学版）2025，Vol.46Issue(3)：288-295,8.DOI:10.11830/ISSN.1000-5013.202410006
虾青素微囊粉的制备与质量评价及其初步药代动力学
Preparation,Quality Evaluation of Astaxanthin Microcapsule Powder and Its Preliminary Pharmacokinetics
摘要
Abstract
Astaxanthin microcapsule powder(Asta-MCs)was prepared by spray drying method.The quality of Asta-MCs was evaluated by parameters such as appearance,particle size,mass fraction,water content,sol-ubility,encapsulation efficiency,drug loading and angle of repose,and pharmacokinetic studies in vivo were also carried out.The results showed that Asta-MCs were orange-red powders with good physicochemical prop-erties.For the self-made Asta-MCs,the half-life was(15.523±3.079)h,the average retention time was(17.787±0.108)h,the peak mass concentration was(1.191±0.060)μg·mL-1,the peak time was 8 h,the area under the blood drug mass concentration-time curve(AUC0～t)was(26.874±2.198)μg·h·mL-1,and the relative bioavailability reached 182.32％.Compared with haematococcus pluvialis oil and commercially a-vailable Asta-MCs,the pharmacokinetic parameters of the self-made Asta-MCs were significantly improved.关键词
虾青素微囊粉/喷雾干燥/雨生红球藻油/质量评价/药代动力学Key words
astaxanthin microcapsule powder/spray drying/haematococcus pluvialis oil/quality evaluation/pharmacokinetics分类
药学引用本文复制引用
许晓英,虞文熙,孙源培,王之,王立强,侯志勇..虾青素微囊粉的制备与质量评价及其初步药代动力学[J].华侨大学学报（自然科学版）,2025,46(3):288-295,8.基金项目
国家重点研发计划项目(2016YFE0101700) （2016YFE0101700）
福建省高校产学合作重大项目(2019Y4007) （2019Y4007）
华侨大学研究生科研创新基金资助项目(18013071019) （18013071019）
