解放军医学杂志2025，Vol.50Issue(4)：490-494,5.DOI:10.11855/j.issn.0577-7402.1671.2024.0704
老年癫痫发作中神经血管单元功能障碍的作用机制研究进展
Research progress on the role of neurovascular unit dysfunction in elderly patients with epileptic seizures
摘要
Abstract
The neurovascular unit(NVU)is the smallest structural unit that maintains the integrity of the blood-brain barrier(BBB),regulates cerebral physiological activities,and maintains the homeostasis of the brain's internal environment.It has become a hot topic in the study of brain physiology and pathological changes.NVU plays a crucial role in age-dependent central nervous system diseases such as cerebral white matter lesions,cognitive impairment,and cerebrovascular disease.Its dysfunction can lead to destruction of BBB integrity,with subsequent protein leakage,immune-inflammatory responses,and alterations in cerebral hemodynamics,all of which can trigger seizures or progression of neurodegenerative disorders.Conversely,seizures can also accelerate NVU dysfunction and promote brain aging.The review summarizes the role of dysfunctional constituent cells of the NVU in the pathogenesis of age-dependent epilepsy and the research progress in related molecular pathways,aiming to provide new perspectives for epilepsy treatment research.关键词
老年癫痫/神经血管单元/血脑屏障/作用机制Key words
epilepsy in the elderly/neurovascular unit/blood-brain barrier/mechanism of action分类
医药卫生引用本文复制引用
刘璇,尹榕..老年癫痫发作中神经血管单元功能障碍的作用机制研究进展[J].解放军医学杂志,2025,50(4):490-494,5.基金项目
This work was supported by the Gansu Provincial Science and Technology Major Program(23ZDFA012),the Natural Science Foundation of Gansu Province(22JR5RA720),and the Gansu Youth Science and Technology Fund(23JRRA1395) 甘肃省科技重大专项(23ZDFA012) （23ZDFA012）
甘肃省自然科学基金(22JR5RA720) （22JR5RA720）
甘肃省青年科技基金(23JRRA1395) （23JRRA1395）
