解放军医学杂志2025，Vol.50Issue(4)：495-503,9.DOI:10.11855/j.issn.0577-7402.0224.2024.0827
AMPK信号通路在脊髓损伤调控及治疗中的作用研究进展
Research progress on AMPK signaling pathway in the regulation and treatment of spinal cord injury
摘要
Abstract
Spinal cord injury(SCI)is a central nervous system disease with high morbidity and disability rates,bringing serious economic and psychological burdens to families and society worldwide.AMP-activated protein kinase(AMPK)is an important sensor in the energy metabolism process in living organisms,which plays a central role in maintaining energy balance.It is currently considered a key target for the prevention and treatment of multiple diseases.Studies have shown that AMPK signaling can regulate autophagy,neuroinflammation,oxidative stress,mitochondrial function and other processes after SCI,thus affecting the pathological process of SCI.This review summarizes the research progress on AMPK signaling pathway involved in the regulation of SCI,in order to provide new ideas for the treatment and drug development of SCI.关键词
脊髓损伤/单磷酸腺苷活化蛋白激酶/病理机制/神经炎症/轴突再生Key words
spinal cord injury/AMP-activated protein kinase/pathological mechanism/neuroinflammation/axon regeneration分类
医药卫生引用本文复制引用
张芝兰,黄晓萌,尚文雅,黄靖,韦慧麟,李冰,任亚锋..AMPK信号通路在脊髓损伤调控及治疗中的作用研究进展[J].解放军医学杂志,2025,50(4):495-503,9.基金项目
This work was supported by the Special Project for Scientific Research of Traditional Chinese Medicine in Henan Province(2022JDZX015,2021JDZY022) 河南省中医药科学研究专项课题(2022JDZX015,2021JDZY022) （2022JDZX015,2021JDZY022）
