军事医学2025，Vol.49Issue(4)：241-249,9.DOI:10.7644/j.issn.1674-9960.2025.04.001
跑台运动对不同月龄小鼠空间学习和记忆能力的调控作用
Regulatory effect of treadmill training on spatial learning and memory abilities in mice of different ages
摘要
Abstract
Objective To investigate the age-dependent modulatory effects of treadmill exercise on spatial learning and memory in mice and to elucidate the potential neurobiological mechanisms underlying these effects.Methods Male C57BL/6J mice at three distinct developmental stages were subjected to a controlled treadmill training protocol for a duration of four weeks.Cognitive performance was assessed in terms of spatial learning and memoryusing a series of behavioral tests.To examine exercise-induced neurogenesis,proliferating adult neural stem cells in the hippocampal region were labeled via intraperitoneal administration of BrdU.Meanwhile,physiological parameters,including body and muscle weight,were monitored throughout the experiment.Results The study revealed significant age-specific effects of treadmill training.In one-month-old mice,exercise intervention markedly enhanced spatial learning and memory,along with increased proliferation of hippocampal neural stem cells,but no significant alterations were observed in body or muscle weight.In six-month-old mice,treadmill training selectively improved spatial memory and led to increased muscle weight.Notably,three-month-old mice exhibited no significant exercise-induced changes in cognitive performance,hippocampal neurogenesis,or muscle weight.Conclusion These findings demonstrate that treadmill exercise exerts significant,age-dependent regulatory effects on spatial learning and memory,with the most pronounced and comprehensive improvements observed in one-month-old mice.The cognitive enhancements may be mediated,at least partially,through exercise-induced promotion of hippocampal neurogenesis.This study provides data for elucidation of the mechanistic basis of exercise-mediated cognitive enhancement and contributes to the potential applications of exercise interventions in cognitive optimization and neuroplasticity across different developmental stages.关键词
跑台运动/空间学习/空间记忆/海马成体神经干细胞增殖Key words
treadmill exercise/spatial learning/spatial memory/proliferation of adult neural stem cells in the hippo-campus分类
生物学引用本文复制引用
郭加庚,陈丽萍,余燕,沈伟,吴海涛..跑台运动对不同月龄小鼠空间学习和记忆能力的调控作用[J].军事医学,2025,49(4):241-249,9.基金项目
国家自然科学基金项目(32171148,32300971) （32171148,32300971）
科技创新2030脑科学与类脑研究重大项目(2021ZD0202500) （2021ZD0202500）
科技部重点研发专项(2021YFA1101801) （2021YFA1101801）
