军事医学2025，Vol.49Issue(4)：273-280,8.DOI:10.7644/j.issn.1674-9960.2025.04.005
音乐理疗对小鼠认知及免疫功能的影响
Effects of music therapy on cognition and immune function of mice
刘银姬 1杜春晓 2陈隽睿 2李宇翔 2李葛 2王智鼎 2韩根成2
作者信息
- 1. 军事科学院军事医学研究院,北京 100850||空军军医大学基础医学院,西安 710032
- 2. 军事科学院军事医学研究院,北京 100850
- 折叠
摘要
Abstract
Objective To investigate the effects of music therapy on cognitive function and immunity of sleep-deprived mice and the potential underlying mechanisms.Methods A novel music therapy was developed by integrating elements from both Western and Chinese music.A sleep-deprived mouse model was established to explore the effects of the music combination on learning and memory of mice using Morris water maze experiments.ELISA was used to detect immune-endocrine indicators in the blood and saliva of mice and to study the effects of this music combination on IgA levels.Transcriptome high-throughput sequencing and B-cell receptor(BCR)repertoire sequencing were adopted to explore the potential mechanisms through which music therapy influenced IgA production.Results The Morris water maze test revealed that the novel music therapy could promote the recovery of cognition and memory of sleep-deprived mice.Additionally,it was found that the music combination could increase IgA levels in both blood and saliva.Transcriptome high-throughput sequencing and BCR sequencing analysis showed that the music combination enhanced the abundance of the IgA immunoglobulin light chain variable region(Igkv4-53)and heavy chain constant region(Igha).Conclusion Music therapy can help restore cognitive function and increase IgA levels in sleep-deprived mice.The mechanism may be related to the enhanced abundance of immunoglobulin light chain variable region(Igkv4-53)and heavy chain constant region(Igha).关键词
音乐治疗/免疫球蛋白A/水迷宫/睡眠剥夺/学习记忆Key words
music therapy/IgA/Morris water maze/sleep deprivation/learning and memory分类
基础医学引用本文复制引用
刘银姬,杜春晓,陈隽睿,李宇翔,李葛,王智鼎,韩根成..音乐理疗对小鼠认知及免疫功能的影响[J].军事医学,2025,49(4):273-280,8.
