临床传统医学和药理学（英文）2025，Vol.6Issue(1)：36-49,14.DOI:10.1016/j.ctmp.2025.200194
Ceropegia variegata:植物化学分析、抗氧化活性及抗菌潜力
Ceropegia variegata:Phytochemical profiling,antioxidant prowess,and antimicrobial potential
Fatima Saleh Naji Bin-Asal 1Adel A.M.Saeed 2Abdul-Rahman Alawi Bin Yahia3
作者信息
- 1. Department of Chemistry Faculty of Education,University of Aden,Aden 009672,Yemen
- 2. Department of Chemistry Faculty of Science,University of Aden,Aden 009672,Yemen
- 3. Department of Pharmaceutical Chemistry,Faculty of Pharmacy,University of Aden,Aden 009672,Yemen
- 折叠
摘要
Abstract
Background:Ceropegia variegata Decne.is a plant traditionally used in medicine,but its full chemical composition and biological potential remain largely unexplored.
Objective:This study aimed to identify the bioactive compounds in C.variegata stem extracts and evaluate their antioxidant and antimicrobial activities.
Methods:Plant stems were sequentially extracted with solvents of increasing polarity.The extracts were analyzed for total phenolic and flavonoid content.Their antioxidant activity was tested by DPPH,FRAPand phosphomolyb-denum assays.Antimicrobial activity was tested against various bacteria and fungi.Liquid chromatography-mass spectrometry(LC-MS)analysis was used to identify compounds in the methanolic extract.
Results:The extracts contained a variety of secondary metabolites,with the ethanol extract being richest in phenolics and the methanol extract in flavonoids.The methanolic extract showed the highest antioxidant activity among the tested extracts,while the chloroform extract showed the highest antimicrobial potency.LC-MS analysis revealed 35 compounds,including phenols,flavonoids,alkaloids,terpenes,glycosides,and fatty acids,which likely contribute to the plant's biological activities.
Conclusion:C.variegata stems are a valuable source of bioactive compounds with significant antioxidant and antimicrobial properties.These findings support the plant's traditional use and suggest its potential for developing natural health products.Further research is needed to isolate and characterize specific bioactive compounds and their mechanisms of action.关键词
Ceropegia variegata Decne./植物化学筛选/抗氧化活性/抗菌活性/LC-MS分析/药用植物Key words
Ceropegia variegata Decne./Phytochemical screening/Antioxidant activity/Antimicrobial activity/LC-MS analysis/Medicinal plants引用本文复制引用
Fatima Saleh Naji Bin-Asal,Adel A.M.Saeed,Abdul-Rahman Alawi Bin Yahia..Ceropegia variegata:植物化学分析、抗氧化活性及抗菌潜力[J].临床传统医学和药理学（英文）,2025,6(1):36-49,14.
