脑胶质瘤患者恶性程度、瘤周水肿与术后癫痫发生的关系及对认知功能的影响OA

Objective To investigate the relationship between postoperative epilepsy and the degree of malignancy of glioma and peritumoral edema,as well as its effect on cognitive function.Methods A total of 100 patients with glioma who underwent glioma resection from December 2019 to June 2024 were retrospectively selected.The patients were divided into ep-ilepsy group(n=36)and non-epilepsy group(n=64)according to whether they had epilepsy within 1 week after surgery.The general data of the two groups were compared,and multivariate logistic regression was used to analyze the risk factors af-fecting postoperative epilepsy in patients with glioma.Propensity score matching method was used to adjust for confounding factors and compare the general data and cognitive function before and after surgery between the two groups.Results There were significant differences in the degree of malignancy,the extent of tumor resection,peritumoral edema,and the history of preoperative epilepsy between the two groups(P＜0.05).High grade of malignancy,peritumoral edema＞2 cm and preop-erative epilepsy history were independent risk factors for postoperative epilepsy in patients with glioma(P＜0.05).After ad-justing the confounding factors by propensity score matching method,there was no significant difference in general data be-tween the two groups(P＞0.05).The scores of Mini-mental State Examination,Montreal Cognitive Assessment,and modi-fied Wechsler Memory Scale in the non-epilepsy group were higher than those in the epilepsy group at 1 week after surgery(P＜0.05).Conclusion High degree of malignancy of glioma,severe peritumoral edema and preoperative epilepsy history are independent risk factors for postoperative epilepsy in patients with glioma,and concurrent epilepsy will affect the recovery of postoperative cognitive function.