南京中医药大学学报2025，Vol.41Issue(5)：582-589,8.DOI:10.14148/j.issn.1672-0482.2025.0582
电针治疗高血压合并失眠症的随机对照临床研究
Randomized Controlled Clinical Study on Electroacupuncture Treatment of Hypertension Combined with Insomnia
摘要
Abstract
OBJECTIVE To observe the effect of electroacupuncture on insomnia symptoms and blood pressure levels in patients with hypertension and insomnia.METHODS A randomized controlled clinical trial was conducted.A total of 60 patients with hyper-tension and insomnia were enrolled in Jiangsu Province Hospital of Chinese Medicine from December 2021 to December 2022 and ran-domly divided into a treatment group and a control group at a ratio of 1:1,with 30 cases in each group.During the treatment period,2 cases dropped out of the control group and 1 case dropped out of the treatment group.Both groups of patients received sleep and hy-pertension health education and conventional hypertension drug treatment.The treatment group was given electroacupuncture interven-tion,and the control group was given sham electroacupuncture intervention.The treatment course of both groups was 4 weeks.Before and after treatment,the Pittsburgh Sleep Quality Index(PSQI),Insomnia Severity Index(ISI)scale and portable polysomnography(PPSG)were used to evaluate the changes in sleep quality of the two groups of patients;home blood pressure measurement(HBPM)was adopted to evaluate the changes in blood pressure levels of the two groups of patients.Spearman correlation analysis and linear re-gression analysis were used to study the relationship between blood pressure levels and PPSG parameters.RESULTS After treatment,only the sleep onset latency(SOL)and sleep efficiency(SE)of the control group were significantly improved(P<0.05);the PSQI,ISI scores,morning and night systolic blood pressure(SBP),and diastolic blood pressure(DBP)of the treatment group were signifi-cantly reduced(P<0.01),which was better than that of the control group(P<0.05,P<0.01);the sleep parameters of PPSG were significantly improved(P<0.01),which was better than that of the control group(P<0.05,P<0.01).The results of Spearman corre-lation analysis showed that the morning SBP level of patients before treatment was related to the wake time after sleep onset(WASO)and the number of micro-arousals(MAS).After treatment,the decrease in the morning SBP of patients was related to the reduction of MAS and the shortening of SOL.CONCLUSION Electroacupuncture can effectively improve the insomnia symptoms and blood pres-sure levels of patients with hypertension.Its therapeutic mechanism may be related to reducing the number of MAS and improving the degree of sleep fragmentation.关键词
高血压/失眠/电针/睡眠碎片化/入睡后清醒时间/微觉醒/清晨收缩压/临床研究Key words
hypertension/insomnia/electroacupuncture/sleep fragmentation/wake time after sleep onset/microarousal/morning systolic blood pressure/clinical research分类
医药卫生引用本文复制引用
王思佳,汪佩,刘成勇,秦珊,王晓秋,吴文忠..电针治疗高血压合并失眠症的随机对照临床研究[J].南京中医药大学学报,2025,41(5):582-589,8.基金项目
国家自然科学基金面上项目(82274631) （82274631）
江苏省科技计划专项(BE2023793) （BE2023793）
国家中医临床研究基地开放课题(JD2022SZXMS01) （JD2022SZXMS01）
江苏省中医药科技发展计划(MS2023026) （MS2023026）
