摘要
Abstract
Objective:To explore the effect of Tiotropium Bromide combined with Doxofylline in the treatment of patients with chronic obstructive pulmonary disease(COPD).Methods:A retrospective analysis was conducted on 78 patients with COPD who finished treatment admitted to Traditional Chinese Medicine Hospital of Tengzhou City from January to December 2024.They were divided into a control group and a study group according to different treatment regimens,with 39 cases in each group.The control group was treated with Doxofylline,while the study group was treated with Tiotropium Bromide in combination with the control group.Both groups were treated for 30 days.The therapeutic effects,pulmonary function indicators,levels of inflammatory factors,exercise endurance,sleep quality and quality of life of the two groups were compared.Results:The effective rate of treatment in the study group was 94.87%,which was higher than 76.93%in the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC in both groups increased compared with those before treatment,and those in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,tumor necrosis factor-α and C-reactive protein in both groups were lower than those before treatment,and the levels in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the 6-Minute Walking Distance of both groups were longer than those before treatment,the study group were longer than the control group,the Pittsburgh Sleep Quality Index scores of both groups were lower than those before treatment,and the study group was lower than the control group,the score of the Comprehensive Quality of Life Questionnaire-74 of both groups was higher than those before treatment,and the study group was higher than the control group,the differences were all statistically significant(P<0.05).Conclusion:Tiotropium Bromide combined with Doxofylline in the treatment of COPD patients can significantly reduce the inflammatory response of their bodies,effectively improve lung function,enhance the exercise endurance,quality of life and sleep of patients,and has clinical application value.关键词
慢性阻塞性肺疾病/噻托溴铵/多索茶碱/炎性因子/生活质量Key words
Chronic obstructive pulmonary disease/Tiotropium Bromide/Doxofylline/Inflammatory factors/Quality of life分类
医药卫生
