山西中医药大学学报2025，Vol.26Issue(4)：379-386,8.DOI:10.19763/j.cnki.2096-7403.2025.04.04
基于数据挖掘探析清代及以前脾虚型消渴用药规律
Exploration of the medication rules of thirst syndrome with spleen-deficiency syndrome before and during the Qing Dynasty based on data mining
摘要
Abstract
Objective:To explore the medication rules of thirst syndrome with spleen-deficiency syndrome before and during the Qing Dynasty through data mining,and provide a reference for the treatment of thirst syndrome with spleen-deficiency syndrome in contemporary times.Methods:The prescriptions for thirst syndrome with spleen-deficiency syn-drome in ancient books before and during the Qing Dynasty,which were collected in the National Library of China(V6.16),were classified and summarized.The prescriptions that met the inclusion criteria were entered into a data table according to clinical manifestations,TCM syndromes,prescription names,and herbal compositions.The software of the Ancient and Modern Prescription Cloud Platform V2.3.9 was used to count the frequency,nature and flavor,meridian tro-pism,efficacy classification of Chinese medicines,and analyze the clinical manifestations.SPSS Modeler 18.0 and SPSS Statistic 26 software were used for association rule analysis and cluster analysis.Results:A total of 36 prescriptions were included,involving 72 kinds of Chinese medicines.High-frequency drugs included Fuling,Renshen,Zhigancao,Rou-gui,Baizhu,Maidong,Shanyao,etc.The nature,flavor and meridian tropism of the drugs were mainly sweet-mild,pungent-warm,and related to the spleen and lung meridian.The efficacy classification of the drugs included tonifying defi-ciency,clearing heat and inducing astringency.The main clinical manifestations were polydipsia,fatigue,emaciation,polyuria,dry mouth,etc.Representative prescriptions included Renshen Decoction,Qiwei Baizhu Powder and Fuling De-coction for spleen-Qi deficiency,and Guixin Powder,Shengma Powder,and Huangqi Liuyi Decoction for spleen-Yang deficiency.Association rule analysis showed that the high-frequency core drugs and core prescription were Rougui-Fuling-Baizhu-Renshen.Cluster analysis yielded 4 categories.Category 1 included Baizhu,Zhigancao,Renshen,Fuling,Rou-gui,and Zhiqiao;category 2 included Shanyao,Shanzhuyu,Shudihuang,and Wuweizi;category 3 included Gegen,Sangbaipi,and Maidong;category 4 included Huanglian and Tianhuafen.These drugs together had the effects of supple-menting Qi,warming Yang,strengthening the spleen,promoting fluid production,nourishing Yin,and relieving thirst.Conclusion:Before and during the Qing Dynasty,the treatment of thirst syndrome with spleen-deficiency syndrome is mainly based on strengthening the spleen,supplementing Qi,and warming Yang,nourishing Yin and promoting fluid pro-duction.This has certain clinical guiding significance for the treatment of thirst syndrome with traditional Chinese medicine.关键词
脾虚/消渴/数据挖掘/用药规律Key words
spleen-deficiency/thirst syndrome/data mining/medication rules分类
医药卫生引用本文复制引用
张怡,郭梦竹,朱少华,赵进东,方朝晖..基于数据挖掘探析清代及以前脾虚型消渴用药规律[J].山西中医药大学学报,2025,26(4):379-386,8.基金项目
新安医学与中医药现代化研究所"揭榜挂帅"项目(2023CXMMTCM024,2023CXMMTCM003) （2023CXMMTCM024,2023CXMMTCM003）
安徽省高等学校科学研究项目(2023AH050782) （2023AH050782）
安徽省卫生健康科研项目(AHWJ2023BAc10002) （AHWJ2023BAc10002）
2023年度新时代育人省级质量工程项目(研究生教育)建设项目(2023gjxslt014) （研究生教育）
安徽省高校优秀拔尖人才培育项目(2022-371) （2022-371）
安徽省卫生健康骨干人才培养对象(2022-392) （2022-392）
安徽省高等学校省级质量工程项目(2021jyxm0834) （2021jyxm0834）
糖脂代谢病教育部重点实验室开放基金(GYDKFXM01) （GYDKFXM01）
安徽省名中医方朝晖工作室(2019-8-515) （2019-8-515）
安徽中医药大学临床科研项目(2021yfylc01) （2021yfylc01）
安徽省中医药大学教学管理研究项目(2021-zlgcfy017) （2021-zlgcfy017）
