有色金属材料与工程2025，Vol.46Issue(2)：43-50,8.DOI:10.13258/j.cnki.nmme.20240223001
基于MoO2@Au NSs的纳米酶SERS传感器用于有效检测心肌梗死
Nano-enzymatic SERS sensor based on MoO2@Au NSs for efficient detection of myocardial infarction
摘要
Abstract
Surface-enhanced Raman spectroscopy(SERS)has attracted great attention in the fields of biology and medicine due to its excellent photostability,non-invasive detection capability and quantitative analysis.Gold nanostars(Au NSs)with spike-like shape was prepared by liquid-phase synthesis method,anda novel nano-enzymatic SERS biosensor was prepared by combining it with flaky MoO2 for the detection of cardiac troponin I(cTn I).The catalytic product of nanoenzymes,oxidized tetramethylbenzidine,was used as a Raman signaling molecule for the highly sensitive detection of cTn I.The SERS sensor based on MoO2@Au NSs showed a good linear range(0-5 ng/mL)and a low detection limit(0.002 5 ng/mL)for the detection of cTnI.The designed SERS sensor has good sensitivity,stability and reproducibility,providing a new way to achieve the point-of-care testing of cTn I.关键词
纳米酶/MoO2@Au NSs/心肌肌钙蛋白/表面增强拉曼散射/生物传感器Key words
nanoenzymes/MoO2@Au NSs/cardiac troponin I/surface-enhanced Raman scattering/biosensors分类
基础医学引用本文复制引用
曹文杰,王丁..基于MoO2@Au NSs的纳米酶SERS传感器用于有效检测心肌梗死[J].有色金属材料与工程,2025,46(2):43-50,8.基金项目
上海市自然科学基金资助项目(19ZR1435200) （19ZR1435200）
