上海针灸杂志2025，Vol.44Issue(5)：529-534,6.DOI:10.13460/j.issn.1005-0957.2025.05.0529
督灸联合揿针治疗小儿变应性鼻炎的疗效观察及对血清IL-17和cAMP水平的影响
Observations on the efficacy of Governor Vessel moxibustion plus thumb-tack needle therapy for pediatric allergic rhinitis and its effect on serum IL-17 and cAMP levels
摘要
Abstract
Objective To observe the clinical efficacy of Governor Vessel moxibustion plus thumb-tack needle therapy for pediatric allergic rhinitis with kidney yang deficiency and its effect on serum interleukin-17(IL-17)and cyclic adenosine monophosphate(cAMP)levels.Method One hundred and twelve pediatric patients with allergic rhinitis were randomized to control and observation groups,with 56 cases in each group.The control group received conventional Western medical treatment and the observation group,Governor Vessel moxibustion plus thumb-tack needle therapy in addition.The TCM symptom score,nasal resistance,eosinophil(EOS)percentage in nasal discharge,and serum cAMP,transforming growth factor-β(TGF-β),cyclic guanosine monophosphate(cGMP)and IL-17 levels were observed in two groups before and after treatment.The clinical therapeutic effects were compared between the two groups.Result The total efficacy rate was 96.4%in the observation group and 82.1%in the control group with a statistically significant difference(P＜0.05).After treatment,the TCM symptom score decreased in the two groups compared with before(P＜0.05)and was lower in the observation group than in the control group(P＜0.05).After treatment,nasal resistance decreased in the two groups compared with before(P＜0.05)and was lower in the observation group than in the control group(P＜0.05).After treatment,EOS percentage decreased in the two groups compared with before(P＜0.05)and was lower in the observation group than in the control group(P＜0.05).After treatment,serum cAMP and TGF-β levels increased in the two groups compared with before(P＜0.05)and were higher in the observation group than in the control group(P＜0.05).After treatment,serum cGMP and IL-17 levels decreased in the two groups compared with before(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).Conclusion On the basis of conventional Western medical treatment,Governor Vessel moxi-bustion plus thumb-tack needle therapy can regulate bodily Treg/Th17 balance,increase serum cGMP and cAMP levels,reduce inflammatory lesion,lower nasal resistance,decrease EOS content,relieve the state of illness and heighten the clinical therapeutic effect in treating patients suffering from allergic rhinitis with kidney yang deficiency.关键词
针灸疗法/督灸/揿针/针药并用/鼻炎,变应性/肾阳虚/儿童/免疫/鼻阻力/环磷酸鸟苷Key words
Acupuncture therapy/Governor Vessel moxibustion/Thumb-tack needle/Acupuncture mediation combined/Rhinitis,allergic/Kidney-yang deficiency/Children/Immunity/Nasal resistance/Cyclic guanosine monophosphate分类
医药卫生引用本文复制引用
闫春迪,李云雷,赵丽萍..督灸联合揿针治疗小儿变应性鼻炎的疗效观察及对血清IL-17和cAMP水平的影响[J].上海针灸杂志,2025,44(5):529-534,6.基金项目
河北省科学技术研究与发展计划(202101A069) （202101A069）
秦皇岛市科学技术研究与开发项目(202301A084) （202301A084）
