上海针灸杂志2025，Vol.44Issue(5)：542-548,7.DOI:10.13460/j.issn.1005-0957.2025.05.0542
改良无痛麦粒化脓灸联合四联疗法治疗Hp阳性脾胃虚弱型慢性萎缩性胃炎的疗效观察
Therapeutic efficacy of modified painless wheat-grain sized cone moxibustion combined with quadruple therapy in the treatment of Hp-positive chronic atrophic gastritis with spleen and stomach weakness pattern
摘要
Abstract
Objective To observe the clinical efficacy of modified painless wheat-grain sized cone moxibustion combined with quadruple therapy in the treatment of Helicobacter pylori(Hp)-positive chronic atrophic gastritis(CAG)with spleen and stomach weakness pattern.Method Ninety cases of Hp-positive CAG with spleen and stomach weakness pattern were divided into a control group and an observation group,with 45 cases in each group.Both groups were treated with quadruple therapy,on the basis of which,the control group took Wei Fu Chun tablets orally,and the observation group used modified painless wheat-grain sized cone moxibustion.The Chinese medicine pattern scores of the two groups were compared before and after treatment and at the follow-up,and the Hp negative conversion rate,serum pepsinogen I(PGI),pepsinogen I/Ⅱ ratio(PGR),gastrin-17(G-17),interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)levels were measured before and after treatment,and the clinical efficacy of the two groups after treatment and at the follow-up was compared.Result The Chinese medicine pattern scores of both groups were lower than those before treatment and were higher in the observation group than in the control group,and the difference was statistically significant(P＜0.05).After treatment,the Hp negative conversion rate of the observation group was 97.8%,which was higher than that of the control group,which was 82.2%(P＜0.05).After treatment,serum PGI,PGR and G-17 levels increased in both groups(P＜0.05),and those of the observation group were higher than those of the control group(P＜0.05).After treatment,the levels of serum IL-6 and TNF-α decreased in both groups compared with those before treatment(P＜0.05),and those of the observation group were lower than those of the control group(P＜0.05);serum IL-10 increased in both groups compared with those before treatment(P＜0.05),and that of the observation group was higher than that of the control group(P＜0.05).The total effective rate after treatment in the observation group was 97.8%,higher than that of 82.2%in the control group(P＜0.05).The total effective rate of the observation group at follow-up was 93.3%,higher than that of the control group(62.2%)(P＜0.05).Conclusion On the basis of quadruple therapy,the treatment of Hp-positive CAG with spleen and stomach weakness pattern with modified painless wheat-grain sized cone moxibustion therapy can significantly improve the clinical symptoms of the patients,and has better long-term efficacy.关键词
灸法/麦粒灸疗法/瘢痕灸/四联疗法/幽门螺杆菌/胃炎,萎缩性/脾胃虚弱Key words
Moxibustion/Wheat-grain sized cone moxibustion therapy/Scarring moxibustion/Quadruple therapy/Helicobacter pylori/Gastritis,atrophic/Spleen and stomach weakness分类
医药卫生引用本文复制引用
杨德鑫,宋旭辉,邵智愚,郭金依,张扬,于清,陈怡文,苏秀贞..改良无痛麦粒化脓灸联合四联疗法治疗Hp阳性脾胃虚弱型慢性萎缩性胃炎的疗效观察[J].上海针灸杂志,2025,44(5):542-548,7.基金项目
山东省中医药管理局齐鲁医派中医药特色技术整理推广项目[鲁卫函(2020)132号] （2020）
