饲料研究2025，Vol.48Issue(7)：91-95,5.DOI:10.13557/j.cnki.issn1002-2813.2025.07.017
漆黄素缓解黄曲霉毒素对小鼠毒性作用的研究
Studies on effect of fisetin in mitigating aflatoxin toxicity in mice
摘要
Abstract
The study aims to explore the effect of fisetin on mitigating aflatoxin toxicity in mice.Sixty 4-week-old Kunming mice were selected,randomly divided into three groups,each with four replicates and five mice(equal sex)per replicate.The control group was fed a basic diet.The AF group received 250 μg/kg of aflatoxin toxicity in the diet.The FI group received 250 μg/kg of aflatoxin toxicity and 50 mg/kg of fisetin.The pre-trial period one weeks,and the formal trial lasted five weeks.The results showed that compared to the control group,the AF group had significantly lower final weight,weight gain,and feed intake(P<0.05),and a significantly higher feed-to-weight ratio(P<0.05).Compared to the AF group,the FI group had significantly higher final weight,weight gain,and feed intake(P<0.05),and a significantly lower feed-to-weight ratio(P<0.05).Compared to the control group,the AF group had significantly higher alanine aminotransferase(ALT)activity(P<0.05)and extremely higher aspartate aminotransferase(AST)activity(P<0.01).Compared to the AF group,the FI group had significantly lower ALT activity(P<0.05)and extremely lower AST activity(P<0.01).Compared to the control group,the AF group had significantly lower catalase(CAT),glutathione peroxidase(GSH-Px)activities and total antioxidant capacity(T-AOC)(P<0.05),and significantly higher malondialdehyde(MDA)content(P<0.05).Compared to the AF group,the FI group had significantly higher GSH-Px activity and T-AOC(P<0.05),and significantly lower MDA content(P<0.05).Compared to the control group,the AF group had significantly higher interleukin-6(IL-6)and interleukin-1β(IL-1β)concentrations(P<0.05),and significantly lower interleukin-4(IL-4),immunoglobulin G(IgG),and immunoglobulin A(IgA)concentrations(P<0.05).Compared to the AF group,the FI group had significantly lower IL-6 and IL-1β concentrations(P<0.05),and significantly higher IL-4 and IgG concentrations(P<0.05).The study shows that fisetin can mitigate aflatoxin toxicity in mice by improving growth performance,biochemical indicators,antioxidant function and regulating immunity.关键词
漆黄素/黄曲霉毒素/生长性能/生化指标/抗氧化/免疫/小鼠Key words
fisetin/aflatoxin toxicity/growth performance/biochemical indicators/antioxidant/immunity/mice分类
农业科技引用本文复制引用
汪孟引,刘昊,李坤,黄佑倩,杨代泽,刘昆,彭涛,秦顺义..漆黄素缓解黄曲霉毒素对小鼠毒性作用的研究[J].饲料研究,2025,48(7):91-95,5.基金项目
天津市生猪现代农业产业技术体系创新团队—功能饲料岗位资助项目(项目编号:ITTPRS2025006) （项目编号:ITTPRS2025006）
和田地区本级科技计划项目(项目编号:202309) （项目编号:202309）
