色谱2025，Vol.43Issue(6)：606-619,14.DOI:10.3724/SP.J.1123.2024.05030
磁增强管内固相微萃取的材料制备及应用进展
Research progress in material preparation and application of magnetism-enhanced in-tube solid-phase microextraction
摘要
Abstract
Selecting a suitable sample preparation method is a significant step prior to chro-matographic separation and detection.Directly analyzing samples instrumentally is difficult owing to the complexity of the sample matrix and the trace concentration of analytes.Most sample preparation methods have disadvantages,including complicated operating procedures,the use of large amounts of organic solvent,and ease of analyte loss during multistep processes;consequently,they do not meet the high analytical sample detection requirements of modern industry.The de-velopment of simple,environmentally friendly,efficient,and rapid preparation methods is a continuing frontier research area in the analytical chemistry field.Among the many available sample preparation techniques,in-tube solid-phase microextraction(IT-SPME)is receiving extensive attention.IT-SPME enriches the target analytes by extracting them to the inner surface of the capillary tube,and has been applied to extract various analytes in the environmental and food fields.IT-SPME is advantageous because it consumes low amounts of organic solvent and capillaries are mechanical stable;consequently,IT-SPME is a promising sample preparation technique.Magnetic field has been introduced to the IT-SPME system to further improve extraction efficiency and se-lectivity,leading to the development of magnetism-enhanced in-tube solid-phase microextraction(ME-IT-SPME)as a new technology.ME-IT-SPME uses magnetic field to separate and enrich targets,with different magnetic-field strengths applied to the extraction column during adsorption and elution.Diamagnetic substances in a paramagnetic medium tend to concentrate in regions where the magnetic field is weak when an external magnetic field is applied.Target analytes are detected chromato-graphically following elution.Conditions are optimized and an analytical method is established and used to detect targets in actual samples,leading to improved extraction sensitivity and precision compared to those obtained using IT-SPME,including shorter analysis time and superior extraction efficiency.This paper reviews the applications of ME-IT-SPME technology in combination with various analytical instruments since its inception in 2012,and analyzes its analysis and detection advantages.Based on hydrophobic interactions,hydrogen bonding,π-π and polarity interactions,coordination,and other extraction mechanisms with analytes,ME-IT-SPME uses innovative functional extraction materials,including nanomaterials,monolithic materials,and magnetic hybrid materials,all of which have high surface areas and numerous adsorption sites.Capillary micro-extraction columns are prepared using open-tubular capillary,particle-filling capillary,or monolithic capillaries.Diverse analytes are detected when ME-IT-SPME is combined with chromatograph,including organic pesticide residues,heavy-metal ions,herbicides,preservatives,and drug mol-ecules.ME-IT-SPME technology is widely used in the environmental-analysis,food-analysis,and biomedical fields.Future,ME-IT-SPME technological developments should include:(1)focus on the reusability and stability of the magnetic extraction material;(2)discovering new extraction materials that are highly enriching and selective in order to analyze a greater variety of targets;(3)further innovating ME-IT-SPME technology by combining it with other more-sensitive analytical methods and considering its use in other fields;(4)connecting different capillaries to simultaneously enrich a variety of analytes;(5)exploring how the higher magnetic field influences extraction efficiency by designing new magnetic-field-regulating devices with small thermal interference;(6)combining the technology with advanced portable analytical instruments to realize real-time target analysis in the field;(7)exploiting immuno-affinitive extraction tubes that can be used to highly efficiently and selectively extract biological macromolecular drugs.关键词
磁增强管内固相微萃取/样品前处理/环境分析/食品分析/生物医药分析/综述Key words
magnetism-enhanced in-tube solid-phase microextraction(ME-IT-SPME)/sample preparation/environmental analysis/food analysis/biomedicine analysis/review分类
化学引用本文复制引用
骆娅娜,陈珈,胡宇宇,高世杰,王艳丽,刘艳明,冯娟娟,孙敏..磁增强管内固相微萃取的材料制备及应用进展[J].色谱,2025,43(6):606-619,14.基金项目
山东省自然科学基金(ZR2023MB006,ZR2023MB154). Shandong Provincial Natural Science Foundation of China(Nos.ZR2023MB006,ZR2023MB154). （ZR2023MB006,ZR2023MB154）
