Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches
Guanghao Zhu Weidong Zhang Wei Liu Guangbo Ge Yani Zhang Shenglan Qi Jianrong Xu Yuan Xiong Zhaoqin Zhang Xixiang Chen Yuanyuan Xie Xiaoqing Guan
Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches
Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches
摘要
关键词
Main proteases(Mpro)/Plant extract/Pu-erh tea/Global chemical analysis/Cysteine-modification profilingKey words
Main proteases(Mpro)/Plant extract/Pu-erh tea/Global chemical analysis/Cysteine-modification profiling引用本文复制引用
Guanghao Zhu,Weidong Zhang,Wei Liu,Guangbo Ge,Yani Zhang,Shenglan Qi,Jianrong Xu,Yuan Xiong,Zhaoqin Zhang,Xixiang Chen,Yuanyuan Xie,Xiaoqing Guan..Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches[J].食品科学与人类健康（英文）,2025,14(5):1864-1873,10.基金项目
We thank the supporting of Shanghai Science and Technology Innovation Action Plans(21 S21900600,20 S21901500,20S21900900)supported by Shanghai Science and Technology Committee,the NSF of China(82273897,81922070,81973286,82104281,82173798),the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004),the Three-year Action Plan for Shanghai TCM Development and Inheritance Program(ZY(2021-2023)-0401),Shanghai Municipal Health Commission's TCM Research Project(2022CX005),Shanghai Municipal Science and Technology Major Project(ZD2021CY001)and Excellent Doctoral Student Cultivation Projects in Key Fields(GJ2022012). （21 S21900600,20 S21901500,20S21900900）
