陕西师范大学学报（自然科学版）2025，Vol.53Issue(3)：43-65,23.DOI:10.15983/j.cnki.jsnu.2025205
膳食生物标志物在营养学研究中的应用与挑战
Advances and challenges in the application of dietary biomarker in nutritional sciences
摘要
Abstract
Dietary biomarkers offer an objective means of assessing contemporary food exposures,serving as an alternative or supplementary tool to self-reported food intake.They are also utilized to explore the functional characteristics of dietary factors.The precise measurement of dietary biomarkers promotes our understandings of the relationship between diet and risk of developing metabolic diseases,helping to achieve personalized and precise nutrition.Metabolomics is a key method for screening dietary biomarkers.This article reviews the research results on dietary biomarkers related to the intake of grains,fruits and vegetables,meat,fish,dairy products,and nuts based on large-scale population cohort studies and randomized controlled dietary intervention studies from 2013 to 2023.It also summarizes the relationship between specific dietary biomarkers and the risk of 35 dietary nutrition related metabolic diseases,including obesity,cardiovascular and cerebrovascular diseases,cancer,and Alzheimer's disease.The current status and challenges of discovering dietary biomarkers based on metabolomics are discussed,in particular on the issues related with research design,complex food composition,inter-individual differences and metabolomics data processing techniques.This review emphasizes the enormous potentials and research prospects of using dietary biomarkers to uncover the relationship between diet and health.关键词
膳食生物标志物/代谢疾病/代谢组学/精准营养Key words
dietary biomarkers/metabolic diseases/metabolomics/precision nutrition分类
医药卫生引用本文复制引用
吕佳瑶,黄翊珺,张诗怡,施琳..膳食生物标志物在营养学研究中的应用与挑战[J].陕西师范大学学报（自然科学版）,2025,53(3):43-65,23.基金项目
国家自然科学基金(32001712) （32001712）
陕西省高校科协青年人才托举计划(20210204) （20210204）
