实用医学杂志2025，Vol.41Issue(9)：1267-1272,6.DOI:10.3969/j.issn.1006-5725.2025.09.001
生物标志物在IgA肾病诊断及预测疾病进展中的作用
The role of biomarkers in the diagnosis and prediction of disease progression of IgA nephropathy
摘要
Abstract
IgA nephropathy(IgAN)is one of the most prevalent forms of primary glomerulonephritis globally and a leading cause of end-stage renal disease(ESRD).The exact pathogenesis and progression mechanisms of IgAN remain unclear.Its clinical manifestations are diverse,with varying degrees of kidney involvement reflected in both clinical presentations and pathological changes.Consequently,responses to treatment and prognoses differ significantly among patients.Currently,renal needle biopsy serves as the gold standard for diagnosing IgAN;how-ever,this invasive procedure is often not well-accepted by patients,limiting its widespread clinical application and complicating disease diagnosis.Therefore,non-invasive biomarkers are crucial for assisting in the diagnosis of IgAN and evaluating the risk of disease progression.Below,we will focus on various serum and urinary biomarkers associated with IgAN at both protein and nucleic acid levels.关键词
IgA肾病/生物标志物/蛋白质/核酸/诊断/进展Key words
IgA nephropathy/biomarkers/protein/nucleic acid/diagnosis/progression分类
临床医学引用本文复制引用
赵璐,支慧文,李亚峰..生物标志物在IgA肾病诊断及预测疾病进展中的作用[J].实用医学杂志,2025,41(9):1267-1272,6.基金项目
国家自然科学基金项目(编号:82170716) （编号:82170716）
