实用医学杂志2025，Vol.41Issue(10)：1453-1459,7.DOI:10.3969/j.issn.1006-5725.2025.10.004
肝癌切除术中肝创面洛铂局部化疗的疗效及安全性
Efficacy and safety of lobaplatin application on liver wound in hepatectomy of patients with primary hepa-tocellular carcinoma
摘要
Abstract
Objective To investigate the efficacy and safety of lobaplatin in promoting liver wound healing following hepatectomy for patients with primary hepatocellular carcinoma.Methods From January 2019 to June 2024,120 patients with primary hepatocellular carcinoma(HCC)at CNLC stages Ia to IIa were randomly divided into an observation group(n=60)and a control group(n=60).The observation group underwent hepatectomy and received lobaplatin application on the liver wound during surgery,while the control group underwent hepatectomy alone without lobaplatin application.All patients were followed up for 66 months.Postoperative levels of ALT,AST,blood creatinine,white blood cells,and platelets were compared between the two groups.Additionally,the incidence of hemorrhage and bile leakage was compared,as well as the recurrence-free survival time after surgery.Results There were no significant differences between the two groups in terms of postoperative ALT,AST,blood creatinine,white blood cell count,or platelet levels(P>0.05).Additionally,no significant differences were ob-served in the incidence of postoperative hemorrhage and bile leakage between the two groups(P>0.05).However,a significant difference was noted in recurrence-free survival time between the groups(P>0.05),with the recurrence-free survival curve indicating a higher recurrence-free survival rate in the observation group compared to the control group(P>0.05).Conclusions Lobaplatin application for liver wound healing in hepatectomy of patients with primary hepatocellular carcinoma represents a feasible,safe,and effective adjuvant therapy.This approach can decrease the early recurrence rate in patients with early-stage primary hepatocellular carcinoma,making it worthy of clinical promotion.关键词
原发性肝癌/洛铂/肝切除术/复发Key words
primary hepatocellular carcinoma/lobaplatin/hepatectomy/recurrence分类
临床医学引用本文复制引用
王毅,刘杰,李绵靖,汤黎..肝癌切除术中肝创面洛铂局部化疗的疗效及安全性[J].实用医学杂志,2025,41(10):1453-1459,7.基金项目
国家自然科学基金地区科学基金项目(编号:82060561) （编号:82060561）
广西壮族自治区中医药管理局自筹经费科研课题(编号:GXZYC20220521) （编号:GXZYC20220521）
广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20210759) （编号:Z20210759）
