实用医学杂志2025，Vol.41Issue(10)：1584-1589,6.DOI:10.3969/j.issn.1006-5725.2025.10.022
活血壮骨方联合经皮椎体成形术治疗骨质疏松性椎体压缩骨折的疗效及对患者骨代谢指标、骨密度的影响
Efficacy of Huoxue Zhuanggu recipe combined with percutaneous vertebroplasty in the treatment of osteo-porotic vertebral compression fracture and its effect on bone metabolism index and bone mineral density
摘要
Abstract
Objective To investigate the efficacy of Huoxue Zhuanggu formula in combination with percuta-neous vertebroplasty(PVP)for the treatment of osteoporotic vertebral compression fractures(OVCF).Methods A total of 114 patients with OVCFs were randomly assigned to three groups:the percutaneous vertebroplasty(PVP)group,the PVP group with routine postoperative treatment(55 cases),and the Huoxue Zhuanggu formula combined with additional supportive therapy group(56 cases).All patients received a 4-week course of treatment following surgery and were followed up for 6 months.Results After 6 months of follow-up,the total effective rate in the Huoxue Zhuanggu group was significantly higher than that in the PVP group(P<0.05).At 4 weeks postoperatively,serum levels of N-terminal osteocalcin,total type I collagen amino-terminal telopeptide,and β-collagen degradation prod-uct were lower in the Huoxue Zhuanggu group compared to the PVP group.Additionally,serum bone morphogenetic protein-2 levels were significantly higher in the Huoxue Zhuanggu group than in the PVP group(P<0.05).After 6 months of follow-up,bone mineral density in Ward's triangle,lumbar spine,and femoral neck,as well as anterior vertebral height percentage and neurological function scores,were significantly higher in the Huoxue Zhuanggu group compared to the PVP group(P<0.05).Conversely,the sagittal kyphosis Cobb angle,anterior vertebral height loss rate,and Oswestry Disability Index score were significantly lower in the Huoxue Zhuanggu group than in the PVP group(P<0.05).Conclusion The combination of Huoxue Zhuanggu recipe and PVP in the treatment of OVCF can regulate patients'bone metabolism indices,enhance bone mineral density,improve vertebral function as well as nerve and lumbar function,thereby achieving a satisfactory therapeutic effect.关键词
骨质疏松性椎体压缩骨折/活血壮骨方/经皮椎体成形术/骨代谢指标/骨密度Key words
osteoporotic vertebral compression fracture/Huoxue Zhuanggu recipe/percutaneous ver-tebroplasty/bone metabolism index/bone density分类
临床医学引用本文复制引用
邓志,谢义松,邹传运..活血壮骨方联合经皮椎体成形术治疗骨质疏松性椎体压缩骨折的疗效及对患者骨代谢指标、骨密度的影响[J].实用医学杂志,2025,41(10):1584-1589,6.基金项目
湖南省中医药科研课题立项项目(编号:A2024035) （编号:A2024035）
湖南省教育厅科学研究项目(编号:22C0193) （编号:22C0193）
