生殖医学杂志2025，Vol.34Issue(5)：588-594,7.DOI:10.3969/j.issn.1004-3845.2025.05.003
不同卵子成熟率对非男性因素不孕患者ICSI周期临床结局的影响
Effect of different oocyte maturation rate on clinical outcomes of ICSI cycle in patients with non-male factor infertility
摘要
Abstract
Objective:To explore the impact of different oocyte maturation rates on embryo development and clinical outcomes in ICSI cycles for infertile patients with non-male factors. Methods:A retrospective study analyzed the data of 531 cycles of patients who previously failed in IVF cycle and then underwent ICSI treatment in Northwest Women's & Children's Hospital from January to December 2023.Based on the proportion of mature oocytes(MⅡ oocytes),the cycles were divided into three groups:the group with oocyte maturation rate not less than 80％(group A,n=312),the group with not less than 60％and less than 80％of oocyte maturation rate(group B,n=148),and the group with less than 60％of oocyte maturation rate(group C,n=71).The clinical outcomes among the groups were compared. Results:There were no statistically significant differences among the three groups in terms of age,years of infertility,body mass index(BMI),the duration and total amount of gonadotropins,normal fertilization rate,oocyte degeneration rate,and blastocyst formation rate(P＞0.05).The proportion of micro-stimulation protocols in group A was significantly higher than those in group B and C(5.13％vs.0.68％and 1.41％,P＜0.05).There were statistically significant differences in the available embryo rates(79.37％vs.71.34％vs.57.45％,P＜0.05)and the rate of high-quality embryos(53.59％vs.45.81％vs.32.98％,P＜0.05)among the three groups,with a continuous decline in both the available embryo rate and the high-quality embryo rate as the oocyte maturation rate decreased.The proportion of canceled transfer cycles due to the risk of OHSS in group B was significantly higher than those in group A and C(20.78％vs.7.95％and 12.00％,P＜0.05).The rates of blastocyst transfer in group A and B were significantly higher than that in group C(27.94％and 28.17％vs.4.76％,P＜0.05).The HCG positive rate in group A was significantly higher than those in group B and C(57.35％vs.42.25％and 42.86％,P＜0.05),but there were no significant differences in clinical pregnancy rates among the groups(50.74％vs.39.44％vs.42.86％,P＞0.05). Conclusions:After excluding a series of confounding factors,a lower oocyte maturation rate negatively impacts the fertilization outcomes and clinical outcomes of ICSI cycles in patients with non-male factor infertility.关键词
卵胞浆内单精子注射/卵子成熟率/临床结局Key words
ICSI/Oocyte maturation rate/Clinical outcome分类
临床医学引用本文复制引用
杨喆东,师娟子,薛侠..不同卵子成熟率对非男性因素不孕患者ICSI周期临床结局的影响[J].生殖医学杂志,2025,34(5):588-594,7.基金项目
陕西省重点产业链项目(2023-ZDLSF-48) （2023-ZDLSF-48）
