生殖医学杂志2025，Vol.34Issue(5)：611-617,7.DOI:10.3969/j.issn.1004-3845.2025.05.006
多囊卵巢综合征孕妇血清SAA、PGRN、sFlt-1水平与胰岛素抵抗及不良妊娠结局的关联性研究
Association between serum SAA,PGRN and sFlt-1 levels and insulin resistance and adverse pregnancy outcomes in pregnant women with PCOS
摘要
Abstract
Objective:To investigate the relationship of serum amyloid A(SAA),progranulin(PGRN)and soluble fms-like tyrosine kinase-1(sFlt-1)levels with insulin resistance(IR)and adverse pregnancy outcomes in pregnant women with PCOS. Methods:A total of 118 young PCOS pregnant women with complete blood samples who underwent regular prenatal examination in Obstetrics and Gynecology Hospital Affiliated to Tongji University from January 2021 to October 2023 were recruited as study subjects.According to the occurrence of IR or not at 22-28 weeks of pregnancy,the enrolled patients were divided into IR group(n=63)and non-IR group(n=55).According to their pregnancy outcomes,the patients were classified into good outcome group(n=79)and adverse outcome group(n=39).The general data and serum levels of SAA,PGRN and sFlt-1 were compared between the IR group and the non-IR group,and the relationship between serum SAA,PGRN,sFlt-1 levels and the occurrence of IR in PCOS patients was analyzed by Pearson's correlation coefficient.The clinical data were compared between good outcome group and adverse outcome group.Logistic regression analysis was used to analyze the influencing factors of adverse pregnancy outcomes in PCOS patients. Results:The proportion of concurrent gestational diabetes mellitus(GDM)and fasting blood glucose level in IR group were significantly higher than those in non-IR group(P＜0.05).The levels of serum SAA and PGRN in the IR group at enrollment and before delivery were significantly higher than those in the non-IR group(P＜0.05),while sFlt-1 level was significantly lower than that in the non-IR group(P＜0.05).Pearson's correlation analysis showed that serum SAA and PGRN levels were positively correlated with HOMA-IR in PCOS patients(P＜0.01),and serum sFlt-1 level was negatively correlated with HOMA-IR(P＜0.01).The proportions of concurrent GDM and hyperandrogenemia at enrollment in adverse outcome group were significantly higher than those in good outcome group(P＜0.05).And before delivery,serum levels of SAA and PGRN were significantly higher(P＜0.05)while serum level of sFlt-1 was significantly lower in adverse outcome group than those in good outcome group(P＜0.05).Multivariate logistic regression analysis revealed that concurrent GDM,hyperandrogenemia,high serum levels of SAA and PGRN,and low serum sFlt-1 level were influencing factors of adverse pregnancy outcomes in PCOS pregnant women(P＜0.05). Conclusions:Serum SAA,PGRN and sFlt-1 levels during pregnancy are associated with IR and pregnancy outcomes in young pregnant women with PCOS.Detection of serum SAA,PGRN and sFlt-1 levels may have certain guiding value for the treatment of young pregnant women with PCOS,but further research and exploration are needed.关键词
多囊卵巢综合征/淀粉样蛋白A/颗粒蛋白前体/可溶性血管内皮生长因子受体1Key words
PCOS/Serum amyloid A/Progranulin/Soluble fms-like tyrosine kinase-1分类
医药卫生引用本文复制引用
陈颖,胡玮珏,洪佳敏,高新..多囊卵巢综合征孕妇血清SAA、PGRN、sFlt-1水平与胰岛素抵抗及不良妊娠结局的关联性研究[J].生殖医学杂志,2025,34(5):611-617,7.基金项目
上海市卫生健康委员会中医药科研项目(20240011) （20240011）
