天津中医药大学学报2025，Vol.44Issue(4)：349-357,9.DOI:10.11656/j.issn.1673-9043.2025.04.10
中医药调控炎症反应信号通路防治肺动脉高压的研究进展
Research progress on the regulation of inflammatory reaction signaling pathways by traditional Chinese medicine to prevent pulmonary hypertension
摘要
Abstract
Pulmonary hypertension(PH)is a clinical syndrome of elevated pulmonary vascular resistance and pulmonary artery pressure caused by a variety of etiological factors,which can lead to increased right ventricular afterload,resulting in right heart failure or even death.The pathogenesis of PH includes inflammatory response,imbalance of vasoactive substances,and abnormal energy metabolism,etc.Inflammatory response is widely involved in the development of PH,which is considered to be a potential key target for the treatment of PH.In recent years,traditional Chinese medicine(TCM)has shown significant efficacy in the treatment of PH,and related multi-component,multi-pathway and multi-target mechanism studies have been widely carried out.This article reviews the progress of research on four inflammatory response signaling pathways,including the NF-κB signaling pathway,MAPK signaling pathway,NLRP3 signaling pathway,and the JAK/STAT signaling pathway,to provide references for the subsequent clinical and basic studies on TCM in the prevention and treatment of PH.关键词
中医药/肺动脉高压/炎症反应/信号通路Key words
traditional Chinese medicine/pulmonary hypertension/inflammatory reaction/signaling pathway分类
临床医学引用本文复制引用
李明伟,王帅,王琳,张泽宇,王慈,王贤良,毛静远..中医药调控炎症反应信号通路防治肺动脉高压的研究进展[J].天津中医药大学学报,2025,44(4):349-357,9.基金项目
国家自然科学基金面上项目(82274437) （82274437）
国家中医药传承创新团队项目(ZYYCXTD-C-202203) （ZYYCXTD-C-202203）
天津市南开区中医药传承创新发展示范试点项目(20240204012). （20240204012）
