西安交通大学学报（医学版）2025，Vol.46Issue(3)：472-479,8.DOI:10.7652/jdyxb202503013
高尿酸血症年轻化趋势:基于2014-2023年健康体检数据的回顾性分析
Trend of young-onset hyperuricemia:a retrospective analysis of health check-up data from 2014 to 2023
摘要
Abstract
Objective To make a retrospective analysis of the prevalence and trend of hyperuricemia(HUA)in the health examination population at The First Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2023 so as to offer insights into the development of preventive strategies.Methods A total of 319 924 individuals who underwent health check-up at the Department of Health Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,from 2014 to 2023 were included in the study.All of them met the research criteria.We collected and analyzed the demographic information and laboratory test results of the participants.Using Logistic regression to investigate the influence of demographic factors and metabolic disorders on HUA in the year 2023.The Cochran-Armitage trend test was used to analyze the changing trend of HUA prevalence over a 10-year period,which was further stratified by gender;multivariable Logistic regression was used to calculate the annual prevalence of HUA after adjusting for confounding factors.Results The overall prevalence of HUA in 2023 was 21.7％(men:30.8％,women:11.0％).Compared with the women,the men had a higher risk of HUA(AOR=3.004,95％CI:2.835-3.184,P＜0.001).Hypertension,dyslipidemia,and obesity were the risk factors for the occurrence of HUA.The effects of age and diabetes on HUA showed gender differences:Increased age was a protective factor for HUA in men,while it was a risk factor in women.Diabetes was only a protective factor in men,and its effect in women was not statistically significant.Trend analysis showed that from 2014 to 2023,the prevalence of HUA presented a gradual upward trend in both genders,with the most significant increase in the 20-39 age group.After adjusting for confounding factors,the prevalence of HUA increased from 22.7％ in 2014 to 31.7％ in 2023 among men,and from 7.0％ in 2014 to 11.5％ in 2023 among women.Conclusion From 2014 to 2023,HUA prevalence demonstrated a gradual increase among people over 20 years old,with the most significant growth seen in the 20-39 age group for both genders.In particular,men aged 20-39 years old were at a high risk for HUA.There is an urgent need to formulate strategies for the prevention and control of HUA.关键词
健康体检/高尿酸血症(HUA)/患病率/变化趋势Key words
health check-up/hyperuricemia(HUA)/prevalence/trend of change分类
医药卫生引用本文复制引用
李鑫,耿辉,马茂..高尿酸血症年轻化趋势:基于2014-2023年健康体检数据的回顾性分析[J].西安交通大学学报（医学版）,2025,46(3):472-479,8.基金项目
陕西省自然科学基金一般项目(No.2024SF-YBXM-097)Supported by the General Project of the Natural Science Foundation of Shaanxi Province(No.2024SF-YBXM-097) （No.2024SF-YBXM-097）
