陕西科技大学学报2025，Vol.43Issue(3)：95-104,124,11.
丝素蛋白掺杂对多糖基可注射自愈合水凝胶性能的影响
The effect of silk fibroin on the properties of polysaccharide-based injectable self-healing hydrogels
摘要
Abstract
Dynamic hydrogel with the integrating properties of injectability,self-healing and adhesion was prepared by doping silk fibroin into polysaccharides based dynamic hydrogel,through the synergistic effect of multiple reversible bonds(imine bond,hydrogen bond,elec-trostatic interaction).The effects of silk fibroin content on the properties of dynamic hydro-gel,such as rheology,self-healing,adhesion,biodegradation and biocompatibility,were inves-tigated.Doping suitable amount of silk fibroin can enhance the mechanical properties and de-lay degradation rate of the dynamic hydrogel,while maintain excellent self-healing and inject-able properties.The dynamic hydrogel loading 2.5 wt％silk fibroin exhibited the maximun mechanical properties(1 650 Pa storage modulus)and degradation performance(50％in two weeks),as well as good adhesion and biocompatibility.关键词
多糖水凝胶/丝素蛋白/可注射/自愈合/粘附Key words
polysaccharide hydrogel/silk fibroin/injectability/self-healing/adhesion引用本文复制引用
陈咏梅,原汶瑾,杨智炫,杨宽,裴文凯,张其清..丝素蛋白掺杂对多糖基可注射自愈合水凝胶性能的影响[J].陕西科技大学学报,2025,43(3):95-104,124,11.基金项目
国家重点研发计划"政府间国际科技创新合作"重点专项项目(2022YFE0104200) （2022YFE0104200）
陕西省科技厅重点研发计划一国际科技合作计划项目(2020KWZ-006) （2020KWZ-006）
高端外国专家引进计划项目(G20200241017) （G20200241017）
联合后勤保障部队研究项目(BLB18J014) （BLB18J014）
