心脑血管病防治2025，Vol.25Issue(4)：9-12,4.DOI:10.3969/j.issn.1009-816x.2025.04.003
血浆中性粒细胞明胶酶相关脂质运载蛋白水平与急性心肌梗死患者预后的相关性
Correlation between plasma neutrophil gelatinase-associated lipocalin levels and prognosis in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the relationship between plasma neutrophil gelatinase-associated lipocalin(NGAL)levels and acute myocardial infarction(AMI),and analyze its association with patient prognosis.Methods A total of 154 patients diagnosed with AMI and receiving percutaneous coronary intervention in Jinhua Central Hospital from January 2020 to April 2022 were selected,with 62 patients who underwent coronary angiography during the same period and had vessel lumen narrowing<50%serving as the control group.One year follow-up was conducted in AMI group,and based on the occurrence of major adverse cardiovascular events(MACE),patients were divided into MACE group(38 cases)and non-MACE group(116 cases)to analyze the influencing factors of MACE in AMI patients.ROC curve analysis was performed to determine the optimal cutoff value of NGAL for predicting MACE occurrence in patients.Results Levels of C-reactive protein(CRP),glycated hemoglobin,brain natriuretic peptide(BNP),low-density lipoprotein(LDL-C),and NGAL in the AMI group were higher than those in the control group,while LVEF was lower than that in control group,with statistical significance with statistical significance(t=2.838,2.231,4.169,2.045,4.116,5.670;P<0.05).The MACE group had older age,higher rates of hyperlipidemia,higher levels of CRP,creatinine,LDL-C,BNP and NGAL than the non-MACE group,and lower levels of LVEF and systolic blood pressure than the non-MACE group,the differences were statistically significant(t/χ2=2.539,6.751,4.036,4.157,2.431,7.052,6.914,3.255,3.586;P<0.05).Logistic regression results indicated that NGAL level and systolic blood pressure were influencing factors for MACE occurrence in AMI patients[OR(95%CI)=1.012(1.005-1.019),0.958(0.921-0.997)].The ROC curve analysis revealed an area under the curve of 0.815 for NGAL in predicting MACE occurrence,with the optimal cutoff value being 148.3 ng/mL,sensitivity of 65.7%,and specificity of 80.1%.Conclusion The level of NGAL increased in AMI patients,and it is associated with the occurrence of MACE one year post-surgery.关键词
急性心肌梗死/血浆中性粒细胞明胶酶相关脂质运载蛋白/主要不良心血管事件Key words
Acute myocardial infarction/Neutrophil gelatinase-associated lipocalin/Major adverse cardiovascular events引用本文复制引用
金强松,胡宪清,蒋泽楠,胡晓康,倪瑜琦,傅慎文..血浆中性粒细胞明胶酶相关脂质运载蛋白水平与急性心肌梗死患者预后的相关性[J].心脑血管病防治,2025,25(4):9-12,4.基金项目
金华市科学技术研究计划项目(2019-3-001b) （2019-3-001b）
金华市科技计划项目(2022-4-106) （2022-4-106）
