新医学2025，Vol.56Issue(5)：519-527,9.DOI:10.12464/j.issn.0253-9802.2024-0284
非编码RNA在非小细胞肺癌放射抗性中的作用
Function of non-coding RNA in radioresistance in non-small cell lung cancer
摘要
Abstract
Lung cancer is not only one of the most common malignancies,but also has the highest mortality rate worldwide,among which non-small cell lung cancer(NSCLC)is the most common subtype.Radiation therapy is one of the main treatments for patients with advanced NSCLC,and the resistance generated during long-term treatment is the key to radiation therapy failure and poor prognosis.With the widespread application of whole genome and RNA sequencing technology and the in-depth exploration of the biological functions of non-coding RNA(ncRNA),there is growing evidence that ncRNA are key regulators in tumorigenesis and development,and different ncRNAs play a role in promoting or inhibiting tumor radioresistance,which are expected to become a useful markers for tumor diagnosis and new targets for tumor treatment.In this article,recent research progress in ncRNA such as microRNA(miRNA),long non-coding RNA(lncRNA),and circular RNA(circRNA)in the radioresistance of NSCLC was reviewed.关键词
肺癌/放射抗性/非编码RNA/微小RNA/长链非编码RNA/环状RNAKey words
Lung cancer/Radioresistance/Non-coding RNA/MiRNA/LncRNA/CircRNA引用本文复制引用
陈梦丹,王华英,俞万钧..非编码RNA在非小细胞肺癌放射抗性中的作用[J].新医学,2025,56(5):519-527,9.基金项目
浙江省教育厅一般科研项目(Y202044084) （Y202044084）
